中国执业药师
中國執業藥師
중국집업약사
CHINA LICENSED PHARMACIST
2014年
8期
3-6
,共4页
唑来膦酸%不良反应%文献分析
唑來膦痠%不良反應%文獻分析
서래련산%불량반응%문헌분석
Zoledronic Acid%Adverse Reactions%Literature Analysis
目的：分析唑来膦酸不良反应发生的规律及特点，为合理用药提供参考。方法：检索唑来膦酸在中国上市以来中国学术期刊全文数据库（CNKI）、维普中文科技期刊数据库（VIP）收载的不良反应文献进行统计分析。结果：唑来膦酸不良反应的个案报道共14例，男性3例，女性11例，年龄最小为43岁，最大为78岁，年龄50岁以上发生率较高（11例，78.6%）；不良反应分别涉及全身性损害、肌肉骨骼系统损害、代谢和营养障碍、肝胆系统损害等。结论：临床医师和药师应了解唑来膦酸致不良反应的规律和特点，加强用药监测，以减少不良反应的发生。
目的：分析唑來膦痠不良反應髮生的規律及特點，為閤理用藥提供參攷。方法：檢索唑來膦痠在中國上市以來中國學術期刊全文數據庫（CNKI）、維普中文科技期刊數據庫（VIP）收載的不良反應文獻進行統計分析。結果：唑來膦痠不良反應的箇案報道共14例，男性3例，女性11例，年齡最小為43歲，最大為78歲，年齡50歲以上髮生率較高（11例，78.6%）；不良反應分彆涉及全身性損害、肌肉骨骼繫統損害、代謝和營養障礙、肝膽繫統損害等。結論：臨床醫師和藥師應瞭解唑來膦痠緻不良反應的規律和特點，加彊用藥鑑測，以減少不良反應的髮生。
목적：분석서래련산불량반응발생적규률급특점，위합리용약제공삼고。방법：검색서래련산재중국상시이래중국학술기간전문수거고（CNKI）、유보중문과기기간수거고（VIP）수재적불량반응문헌진행통계분석。결과：서래련산불량반응적개안보도공14례，남성3례，녀성11례，년령최소위43세，최대위78세，년령50세이상발생솔교고（11례，78.6%）；불량반응분별섭급전신성손해、기육골격계통손해、대사화영양장애、간담계통손해등。결론：림상의사화약사응료해서래련산치불량반응적규률화특점，가강용약감측，이감소불량반응적발생。
Objective:To analyze the general rules and characteristics of the adverse drug reactions(ADRs)induced by zoledronic acid so as to provide a reference for rational drug use in clinical practice.Methods:ADRs of zoledronic acid were retrieved from CNKI and VIP database since it was put into market in China and the data was analyzed statistically. Results:Totally 14 cases of ADRs(including 3 men and 11 women)caused by zoledronic acid were collected. The youngest patient was 43 years old and the oldest was 78 years old. The patients over the age of 50 showed the highest incidence(n= 11,78.6%). Their ADRs were involved in systemic damage such as musculo-skeletal system damage, metabolic and nutritional disorders, and hepatobiliary system damage,etc.Conclusion:Clinicians and pharmacists should understand the rules and characteristics of the ADRs induced by zoledronic acid and strengthen monitoring on drug use so as to reduce the incidence of ADR.
