CAJ | 학술논문

目的：探讨白细胞介素-9（IL-9）在急性脑梗死中的临床意义。方法选择急性脑梗死患者75例（病例组）和健康体检者50名（正常对照组）。采用酶联免疫吸附试验（ELISA）检测两组血清IL-9及C反应蛋白（ CRP）水平，比较两组间的差异；另根据脑梗死面积的大小分为小面积梗死组和大面积梗死组，测定两组血清IL-9及CRP水平并进行比较；同时分析IL-9与CRP之间的关系。结果病例组血清IL-9和CRP水平显著高于对照组（P＜0.01）；大面积梗死组IL-9和CRP水平较小面积梗死组显著升高（P＜0.01）；血清IL-9与CRP水平呈正相关（ r＝0.896，P＝0.000）。结论 IL-9可能参与了急性脑梗死的发生发展，其机制可能与IL-9介导的炎症反应有关。
목적：탐토백세포개소-9（IL-9）재급성뇌경사중적림상의의。방법선택급성뇌경사환자75례（병례조）화건강체검자50명（정상대조조）。채용매련면역흡부시험（ELISA）검측량조혈청IL-9급C반응단백（ CRP）수평，비교량조간적차이；령근거뇌경사면적적대소분위소면적경사조화대면적경사조，측정량조혈청IL-9급CRP수평병진행비교；동시분석IL-9여CRP지간적관계。결과병례조혈청IL-9화CRP수평현저고우대조조（P＜0.01）；대면적경사조IL-9화CRP수평교소면적경사조현저승고（P＜0.01）；혈청IL-9여CRP수평정정상관（ r＝0.896，P＝0.000）。결론 IL-9가능삼여료급성뇌경사적발생발전，기궤제가능여IL-9개도적염증반응유관。
Objective To investigate the clinical significance of interleukin-9(IL-9) in acute cerebral in-farction.Methods The serum IL-9 and CRP levels in 75 cases of acute cerebral infarction in the case group and in 50 healthy cases in control group were tested by enzyme linked immune sorbent assay ( ELISA) .The differences in IL-9 and CRP between two groups , and between the small area cerebral infarction and large area cerebral infarction were compared , and the relationship between IL-9 and CRP was analyzed .Results IL-9 and CRP levels in serum the case group were significantly higher than those in control group ( P<0.01 );the serum IL-9 and CRP levels in cases of large area infarction were higher than those in cases of small area infarction ( P<0.01 );There was a positive correla-tion between serum IL-9 and CRP level ( r=0.896 , P=0.000 ) .Conclusion IL-9 may participate in the occurrence and development of acute cerebral infarction , and its mechanism may be related to the IL-9 mediated inflammatory re-action.