CAJ | 학술논문

目的：探讨普拉克索治疗帕金森病（parkinson′s disease，PD）晚期病人的疗效。方法将32例已经使用复方左旋多巴制剂治疗2～6年以上的Hoehn-Yahr Ⅳ～Ⅴ级的PD患者作为研究对象，加用普拉克索治疗12周后对疗效进行评估。运动症状：治疗前后采用PD评定量表（ UPDRS）进行评估。非运动症状：主要观察焦虑、抑郁、睡眠障碍症状的变化，并记录患者的不良反应。结果治疗后患者UPDRS评分明显下降，差异有统计学意义（ P＜0.01）。患者在治疗过程中未发生严重不良反应。结论晚期PD患者在应用复方左旋多巴治疗的基础上添加普拉克索治疗可以减少左旋多巴用量，有效缓解运动及非运动症状，明显提高生活质量。
목적：탐토보랍극색치료파금삼병（parkinson′s disease，PD）만기병인적료효。방법장32례이경사용복방좌선다파제제치료2～6년이상적Hoehn-Yahr Ⅳ～Ⅴ급적PD환자작위연구대상，가용보랍극색치료12주후대료효진행평고。운동증상：치료전후채용PD평정량표（ UPDRS）진행평고。비운동증상：주요관찰초필、억욱、수면장애증상적변화，병기록환자적불량반응。결과치료후환자UPDRS평분명현하강，차이유통계학의의（ P＜0.01）。환자재치료과정중미발생엄중불량반응。결론만기PD환자재응용복방좌선다파치료적기출상첨가보랍극색치료가이감소좌선다파용량，유효완해운동급비운동증상，명현제고생활질량。
Objective To explore the efficacy of pramipexole in the treatment of advanced Parkinson′s dis-ease(PD).Methods Thirty-two PD patients with Hoehn-YahrⅣ~Ⅴhas been treated with levodopa more than 2~6 years as the research object .Pramipexole was added , and evaluated the curative effect after 12 weeks.Motor symp-toms:PD rating scale(UPDRS) was used to evaluate treatment effect;Non-motor symptoms: the changes were ob-served of the anxiety , depression, sleep disorder symptoms , and adverse reactions of patients were recorded .Results The UPDRS scores of PD patients significantly decreased after treatment , and the difference was statistically signifi-cant(P<0.01).All the patients has not suffered from serious adverse reactions in the process of treatment .Conclu-sion For advanced PD patients adding pramipexole treatment on the basis of levodopa can effectively alleviate the motor symptoms and non-motor symptoms, obviously improve the quality of life at the same time .