CAJ | 학술논문

弓形虫RO Ps包括数十种速殖子分泌蛋白，在虫体的入侵、纳虫泡形成、增殖、出胞和逃避宿主细胞效应分子的攻击中发挥重要作用。RO Ps属于蛋白激酶家族，其部分成员虽具有激酶结构域，但是由于某些关键位点的突变，失去了磷酸化宿主信号分子的作用，故称为假激酶。近年的研究认为，假激酶同样具有重要功能，例如通过变构调节激酶的活性；作为支架蛋白促进蛋白质分子间的相互作用。本文对弓形虫假激酶的结构特点和部分假激酶的功能进行了综述，对于研究弓形虫RO Ps与宿主的相互作用、候选分子疫苗筛选和药物研发具有参考意义。
궁형충RO Ps포괄수십충속식자분비단백，재충체적입침、납충포형성、증식、출포화도피숙주세포효응분자적공격중발휘중요작용。RO Ps속우단백격매가족，기부분성원수구유격매결구역，단시유우모사관건위점적돌변，실거료린산화숙주신호분자적작용，고칭위가격매。근년적연구인위，가격매동양구유중요공능，례여통과변구조절격매적활성；작위지가단백촉진단백질분자간적상호작용。본문대궁형충가격매적결구특점화부분가격매적공능진행료종술，대우연구궁형충RO Ps여숙주적상호작용、후선분자역묘사선화약물연발구유삼고의의。
Toxoplasma gondii rhoptry proteins (ROPs) include dozens of proteins secreted by tachyzoites ,these ROPs are known to be critical for several processes such as invasion ,parasitophorous vacuole establishment ,proliferation ,egress and getting out of host immune protection .ROPs belong to the protein kinase family and have classic kinase domain ,however ,most of the members are designated as pseudokinases due to the lack of critical catalytic residues that are normally required for phos-phorylation of host signal molecules .Recent studies indicated that pseudokinases also have important functions ,such as regula-ting kinase activity by allosteric and promoting the interactions between proteins as scaffolds .In this paper ,we summarize the pseudokinases structural characteristics and some pseudokinases functions ,for the study of toxop lasma gondii and host interac-tion mechanisms ,molecular vaccines screening and drugs design .