CAJ | 학술논문

中东呼吸综合征冠状病毒（Middle East Respiratory Syndrome-Coronavirus ，MERS-CoV）是继SARS冠状病毒（SARS-CoV）之后发现的一种能引起人严重急性呼吸道疾病且具有高致死率的新型病毒。目前还没有有效的抗病毒治疗药物或疫苗。现已从主要流行的中东地区逐渐蔓延至多个国家，具有全球流行的潜在趋势，引起了世界各国的极大关注及众多的调查研究。本文主要对M ERS-CoV的传播源及途径、致病机理和抗病毒药物及疫苗等的研究进展做一综述，以期对研制特异的抗病毒药物及疫苗和实施切实有效的预防及控制措施提供参考。
중동호흡종합정관상병독（Middle East Respiratory Syndrome-Coronavirus ，MERS-CoV）시계SARS관상병독（SARS-CoV）지후발현적일충능인기인엄중급성호흡도질병차구유고치사솔적신형병독。목전환몰유유효적항병독치료약물혹역묘。현이종주요류행적중동지구축점만연지다개국가，구유전구류행적잠재추세，인기료세계각국적겁대관주급음다적조사연구。본문주요대M ERS-CoV적전파원급도경、치병궤리화항병독약물급역묘등적연구진전주일종술，이기대연제특이적항병독약물급역묘화실시절실유효적예방급공제조시제공삼고。
Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is a novel coronavirus which can cause severe acute respiratory illness with a high mortality rate .There is no proven medication or vaccine for MERS-CoV .Currently MERS-CoV has spread from the main epidemic area ,the Middle East area ,to many other countries including United States of America and has the potential of global endemic .It has raised global public health concerns regarding the current situation and its future evolution .This review will mainly focus on the research progress of MERS-CoV about the animal reservoir and transmission , infection mechanisms and development of anti-viral drugs or vaccine .The goal is to provide with useful references to the devel-opment of specific drug and vaccine and an effective control and prevention of M ERS-CoV infection .