世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
WORLD JOURNAL OF TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
8期
856-858
,共3页
龚敏%白春英%宋林宏%赵英英%孙守芳%陈文文
龔敏%白春英%宋林宏%趙英英%孫守芳%陳文文
공민%백춘영%송림굉%조영영%손수방%진문문
I GR%知柏地黄丸%生活方式干预%胰岛素抵抗%胰岛β细胞功能
I GR%知柏地黃汍%生活方式榦預%胰島素牴抗%胰島β細胞功能
I GR%지백지황환%생활방식간예%이도소저항%이도β세포공능
IGR%Zhibaidihuang Wan%Life Style Intervention%Insulin Resistance%Islet β-Cell Function
目的：观察知柏地黄丸对糖调节受损（IGR）患者的临床疗效及对胰岛素抵抗、胰岛β细胞功能的影响。方法176例IGR患者，随机分为治疗组与对照组，观察结束共脱落及剔除病例19例，纳入统计病例157例，治疗组77例，对照组80例，两组均给予教育及生活方式干预，治疗组在其基础上给予知柏地黄丸口服，治疗12个月后，观察两组体重指数（BMI ）、HOMA 胰岛素分泌指数（HOMA-β）、早期胰岛素分泌指数（EISI）及HOMA胰岛素抵抗指数（HOMA-IR）的改变。结果两组患者的BMI及HOMA-IR较治疗前均有下降，HOMA -β明显升高，差异有统计学意义（P＜0．05，P＜0．01）；与对照组比较，治疗组治疗后HOMA-IR下降，EISI及HOMA-β升高，差异有统计学意义（P＜0．05，P＜0．01）。结论知柏地黄丸能减轻胰岛素抵抗，改善胰岛β细胞功能，延缓或预防IGR患者向2型糖尿病（T2DM）发展。
目的：觀察知柏地黃汍對糖調節受損（IGR）患者的臨床療效及對胰島素牴抗、胰島β細胞功能的影響。方法176例IGR患者，隨機分為治療組與對照組，觀察結束共脫落及剔除病例19例，納入統計病例157例，治療組77例，對照組80例，兩組均給予教育及生活方式榦預，治療組在其基礎上給予知柏地黃汍口服，治療12箇月後，觀察兩組體重指數（BMI ）、HOMA 胰島素分泌指數（HOMA-β）、早期胰島素分泌指數（EISI）及HOMA胰島素牴抗指數（HOMA-IR）的改變。結果兩組患者的BMI及HOMA-IR較治療前均有下降，HOMA -β明顯升高，差異有統計學意義（P＜0．05，P＜0．01）；與對照組比較，治療組治療後HOMA-IR下降，EISI及HOMA-β升高，差異有統計學意義（P＜0．05，P＜0．01）。結論知柏地黃汍能減輕胰島素牴抗，改善胰島β細胞功能，延緩或預防IGR患者嚮2型糖尿病（T2DM）髮展。
목적：관찰지백지황환대당조절수손（IGR）환자적림상료효급대이도소저항、이도β세포공능적영향。방법176례IGR환자，수궤분위치료조여대조조，관찰결속공탈락급척제병례19례，납입통계병례157례，치료조77례，대조조80례，량조균급여교육급생활방식간예，치료조재기기출상급여지백지황환구복，치료12개월후，관찰량조체중지수（BMI ）、HOMA 이도소분비지수（HOMA-β）、조기이도소분비지수（EISI）급HOMA이도소저항지수（HOMA-IR）적개변。결과량조환자적BMI급HOMA-IR교치료전균유하강，HOMA -β명현승고，차이유통계학의의（P＜0．05，P＜0．01）；여대조조비교，치료조치료후HOMA-IR하강，EISI급HOMA-β승고，차이유통계학의의（P＜0．05，P＜0．01）。결론지백지황환능감경이도소저항，개선이도β세포공능，연완혹예방IGR환자향2형당뇨병（T2DM）발전。
Objective To observe the clinical efficacy of Zhibaidihuang Wan on impaired glucose regulation(IGR)and the impacts on insulin resistance(IR)and islet β-cell function.Methods One hun-dred and seventy-six cases of IGR were randomized into a treatment group and a control group.At the end of observation,1 9 cases of them were lost and removed.Totally,1 57 cases were included in final statistical anal-ysis,77 cases in the treatment group and 80 cases in the control group.The education and life style interven-tion was given in the two groups.Additionally,Zhibaidihuang Wan was prescribed for oral administration in the treatment group.In 1 2 months of treatment,BMI,HOMA-β,EISI and HOMA-IR were observed in the two groups.Results BMI and HOMA-IR were reduced as compared with those before treatment in the two groups and HOMA -βwas increased apparently,indicating the significant difference in comparison (P<0.05,P<0.01 ).After treatment,HOMA -IR was reduced,and EISI and HOMA -HOMA -βwere in-creased in the treatment group as compared with the control group,indicating the significant difference(P<0.05,P<0.01 ).Conclusion Zhibaidihuang Wan alleviates IR,improves islet β-cell function,delays the progression of or prevents from T2DM in IGR patients.
