CAJ | 학술논문

目的：观察补肾健脾活血颗粒联合西药治疗早发型重度子痫前期的疗效。方法采用前瞻性研究方法，将患者按入院顺序随机分为联合组和对照组，联合组在应用硫酸镁及其他西药治疗的基础上加用补肾健脾活血颗粒，对照组应用硫酸镁及其他西药治疗。治疗前后观察两组血压变化和24 h尿蛋白定量、延长孕周时间的差异。结果两组患者在用药前后血压控制、24 h尿蛋白定量及延长孕周时间比较有明显差异（ P＜0.05）。结论补肾健脾活血颗粒联合西药治疗早发型重度子痫前期疗效显著，机理为该药物滋补肾阴、健脾利湿、镇静安神、活血化瘀，改善患者血液高凝状态，减少并发症发生。
목적：관찰보신건비활혈과립연합서약치료조발형중도자간전기적료효。방법채용전첨성연구방법，장환자안입원순서수궤분위연합조화대조조，연합조재응용류산미급기타서약치료적기출상가용보신건비활혈과립，대조조응용류산미급기타서약치료。치료전후관찰량조혈압변화화24 h뇨단백정량、연장잉주시간적차이。결과량조환자재용약전후혈압공제、24 h뇨단백정량급연장잉주시간비교유명현차이（ P＜0.05）。결론보신건비활혈과립연합서약치료조발형중도자간전기료효현저，궤리위해약물자보신음、건비리습、진정안신、활혈화어，개선환자혈액고응상태，감소병발증발생。
Objective To analyze curative effect of Bushenjianpihuoxue granule combined with western medicine on the treatment of early onset of severe preeclampsia.Methods Patients with early onset of severe preeclampsia were divided into two groups randomly.The treatment group were treated by Bushenjianpihuoxue granule combined with magnesium and other western medicine .The control group were treated only by magnesium and other western medicine.Blood pressure , 24 -hour urinary protein excretion and the time of prolonged gestational age were measured.Results Blood pressure descended , 24 -hour urinary protein excretion reduced significantly and the gestational age increased in treatment group ( P<0.05 ).Conclusion Bushenjianpihuoxue granule combined with magnesium and other western medicine on the treatment of early onset of severe preeclampsia has significant effect , its mechanism may be related with nourishing kidney , tonifying spleen , tranquilizing and allaying excitement , promoting blood circulation to remove blood stasis , to improve the patients′hypercoagulable states and reduce complications.