化学与生物工程
化學與生物工程
화학여생물공정
CHEMISTRY & BIOENGINEERING
2014年
8期
39-40,63
,共3页
齐燕南%邢莹莹%奚涛
齊燕南%邢瑩瑩%奚濤
제연남%형형형%해도
人乳腺癌细胞%格尔德霉素%SMYD3%核转位
人乳腺癌細胞%格爾德黴素%SMYD3%覈轉位
인유선암세포%격이덕매소%SMYD3%핵전위
human breast cancer cells%geldanamycin%SMYD3%nuclear translocation
采用 Western blot 检测法研究了不同浓度的格尔德霉素对人乳腺癌细胞 MDA-MB-231中 SET 和 MYND结构域蛋白3(SMYD3)核转位的影响,采用 MTT 比色法检测了格尔德霉素对人乳腺癌细胞 MDA-MB-231增殖的影响。结果表明:格尔德霉素可以抑制 SMYD3的核转位,并且这种抑制作用是浓度依赖性的;与对照组相比,人乳腺癌细胞 MDA-MB-231的增殖速率被显著地抑制了。说明格尔德霉素可以通过抑制 SMYD3的核转位显著抑制人乳腺癌细胞 MDA-MB-231的增殖。
採用 Western blot 檢測法研究瞭不同濃度的格爾德黴素對人乳腺癌細胞 MDA-MB-231中 SET 和 MYND結構域蛋白3(SMYD3)覈轉位的影響,採用 MTT 比色法檢測瞭格爾德黴素對人乳腺癌細胞 MDA-MB-231增殖的影響。結果錶明:格爾德黴素可以抑製 SMYD3的覈轉位,併且這種抑製作用是濃度依賴性的;與對照組相比,人乳腺癌細胞 MDA-MB-231的增殖速率被顯著地抑製瞭。說明格爾德黴素可以通過抑製 SMYD3的覈轉位顯著抑製人乳腺癌細胞 MDA-MB-231的增殖。
채용 Western blot 검측법연구료불동농도적격이덕매소대인유선암세포 MDA-MB-231중 SET 화 MYND결구역단백3(SMYD3)핵전위적영향,채용 MTT 비색법검측료격이덕매소대인유선암세포 MDA-MB-231증식적영향。결과표명:격이덕매소가이억제 SMYD3적핵전위,병차저충억제작용시농도의뢰성적;여대조조상비,인유선암세포 MDA-MB-231적증식속솔피현저지억제료。설명격이덕매소가이통과억제 SMYD3적핵전위현저억제인유선암세포 MDA-MB-231적증식。
Through Western blot analysis,the effect of geldanamycin on the nuclear translocation of SET and MYND domain-containing protein 3 (SMYD3)in human breast cancer cells MDA-MB-231 was studied. MTT Colorimetric method was used to explore the effect of geldanamycin on the proliferation of human breast cancer cells MDA-MB-231.It was shown that the addition of geldanamycin with different concentrations could suppress the nuclear translocation of SMYD3 in a dose-dependent manner.The cell growth rate reduced signifi-cantly compared with the control cells.The results showed that geldanamycin could inhibit the proliferation of human breast cancer cells MDA-MB-231 by suppressing the nuclear translocation of SMYD3.