风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2014年
8期
21-24
,共4页
翟沛%孙永强%孙建华
翟沛%孫永彊%孫建華
적패%손영강%손건화
骨关节炎,原发性%全膝关节置换%隐性失血%氨甲环酸注射液
骨關節炎,原髮性%全膝關節置換%隱性失血%氨甲環痠註射液
골관절염,원발성%전슬관절치환%은성실혈%안갑배산주사액
osteoarthritis,primary%total knee replacement%occult blood loss%tranexamic acid injection
目的：观察运用氨甲环酸注射液治疗原发性骨关节炎首次单膝关节表面置换后隐性失血的疗效。方法：将92例初次单膝关节置换患者随机分为治疗组和对照组，每组46例。治疗组在完成手术闭合创口前，关节腔注射600 mg·6 mL-1氨甲环酸注射液，对照组关节腔注射质量分数0.9%氯化钠注射液6 mL，术后常规留置引流管，夹闭引流管3 h；后打开引流管，测量术后红细胞压积、患肢周径、显性失血量；分别计算总失血量和隐性失血量，对比计算结果。所有患者术后7d行双下肢彩超检查。结果：治疗组的总失血量、患肢周径变化比较，差异无统计学意义（P>0.05）；总失血显量、隐性失血量均小于对照组（P<0.05）。所有患者均无血栓形成。结论：氨甲环酸注射液的及时有效剂量用药，能够明显减少初次膝关节置换术后隐性失血量，同时减少输血量和输血率，对术后下肢深静脉血栓的形成无明显影响。
目的：觀察運用氨甲環痠註射液治療原髮性骨關節炎首次單膝關節錶麵置換後隱性失血的療效。方法：將92例初次單膝關節置換患者隨機分為治療組和對照組，每組46例。治療組在完成手術閉閤創口前，關節腔註射600 mg·6 mL-1氨甲環痠註射液，對照組關節腔註射質量分數0.9%氯化鈉註射液6 mL，術後常規留置引流管，夾閉引流管3 h；後打開引流管，測量術後紅細胞壓積、患肢週徑、顯性失血量；分彆計算總失血量和隱性失血量，對比計算結果。所有患者術後7d行雙下肢綵超檢查。結果：治療組的總失血量、患肢週徑變化比較，差異無統計學意義（P>0.05）；總失血顯量、隱性失血量均小于對照組（P<0.05）。所有患者均無血栓形成。結論：氨甲環痠註射液的及時有效劑量用藥，能夠明顯減少初次膝關節置換術後隱性失血量，同時減少輸血量和輸血率，對術後下肢深靜脈血栓的形成無明顯影響。
목적：관찰운용안갑배산주사액치료원발성골관절염수차단슬관절표면치환후은성실혈적료효。방법：장92례초차단슬관절치환환자수궤분위치료조화대조조，매조46례。치료조재완성수술폐합창구전，관절강주사600 mg·6 mL-1안갑배산주사액，대조조관절강주사질량분수0.9%록화납주사액6 mL，술후상규류치인류관，협폐인류관3 h；후타개인류관，측량술후홍세포압적、환지주경、현성실혈량；분별계산총실혈량화은성실혈량，대비계산결과。소유환자술후7d행쌍하지채초검사。결과：치료조적총실혈량、환지주경변화비교，차이무통계학의의（P>0.05）；총실혈현량、은성실혈량균소우대조조（P<0.05）。소유환자균무혈전형성。결론：안갑배산주사액적급시유효제량용약，능구명현감소초차슬관절치환술후은성실혈량，동시감소수혈량화수혈솔，대술후하지심정맥혈전적형성무명현영향。
Objective:To observe the curative effect of the treatment of occult blood loss of prima-ry osteoarthritis after the knee surface replacement for the ifrst time with tranexamic acid injection.Methods:92 cases undergoing primary single knee replacement were randomly and equally divided into a treatment group and a control group.The treatment group were given an intra-articular injection of tranexamic acid injection (600 mg·6 mL-1) before wound healing and the control group were given a joint cavity injection of sodium chloride injection (6 mL) with 0.9%of the quality score.Drainage tube was detained routinely after operation and closed for 3 hours;opened the drainage tube then to detect the HCT,circumference and diameter of the affect-ed limb,and the dominant amount of blood loss.Calculated the total blood loss and occult blood loss,comparing their results.Both lower limbs were examined by ultrasonography after 7 days’ operation.Results:In the treatment group,the total blood loss and the change of circumference and diameter of the affected limb had no signiifcant difference before and after treatment (P>0.05);the total blood loss and the occult blood loss were both less than those of the control group (P<0.05);there were no thrombosis for all the patients.Conclusion:Timely and effective dose of tranexamic acid injection could obviously reduce the occult blood loss of knee joint replacement for the ifrst time and reduce the amount of blood transfusion and transfusion rate,having no obvious effects on the formation of deep venous thrombosis of lower extremity after operation.
