实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
9期
15-17
,共3页
冯勋刚%郑俊萍%董海新%杨君
馮勛剛%鄭俊萍%董海新%楊君
풍훈강%정준평%동해신%양군
脑梗死%阿司匹林%抗药性%受体,N-甲基-D-天冬氨酸
腦梗死%阿司匹林%抗藥性%受體,N-甲基-D-天鼕氨痠
뇌경사%아사필림%항약성%수체,N-갑기-D-천동안산
Brain infarction%Aspirin%Drug resistance%Receptors,N - methyl - D - aspartate
目的:探讨脑梗死患者血小板 N -甲基- D -天冬氨酸(NMDA)受体表达与阿司匹林抵抗(AR)的相关性。方法选择2011年8月-2013年7月在我院神经内科住院的脑梗死患者45例为脑梗死组,同期在我院体检中心体检健康者40例为对照组。脑梗死患者确诊后即开始规律服用阿司匹林(100 mg/ d),检测两组受检者 NMDA 受体表达水平和血小板聚集率。结果对照组受检者 NMDA 受体相对表达量为(0.11±0.07),低于脑梗死组-治疗前患者的(0.32±0.12)(P ﹤0.001),脑梗死组-治疗前患者 NMDA 受体相对表达量低于脑梗死组-治疗后患者的(0.69±0.15)(P ﹤0.001)。对照组受检者血小板聚集率为(32.38±11.38)%,脑梗死组-治疗后患者为(43.81±14.40)%,均低于脑梗死组-治疗前患者的(57.00±18.96)%。Spearman 相关分析结果显示,对照组受检者、脑梗死组-治疗前患者、脑梗死组-治疗后患者血小板 NMDA 受体相对表达量与血小板聚集率均无直线相关性( P ﹥0.05)。结论脑梗死患者血小板 NMDA 受体表达水平升高,阿司匹林可上调脑梗死患者血小板 NMDA 受体的表达, NMDA 受体表达增加可能是脑梗死患者发生 AR 的重要原因。
目的:探討腦梗死患者血小闆 N -甲基- D -天鼕氨痠(NMDA)受體錶達與阿司匹林牴抗(AR)的相關性。方法選擇2011年8月-2013年7月在我院神經內科住院的腦梗死患者45例為腦梗死組,同期在我院體檢中心體檢健康者40例為對照組。腦梗死患者確診後即開始規律服用阿司匹林(100 mg/ d),檢測兩組受檢者 NMDA 受體錶達水平和血小闆聚集率。結果對照組受檢者 NMDA 受體相對錶達量為(0.11±0.07),低于腦梗死組-治療前患者的(0.32±0.12)(P ﹤0.001),腦梗死組-治療前患者 NMDA 受體相對錶達量低于腦梗死組-治療後患者的(0.69±0.15)(P ﹤0.001)。對照組受檢者血小闆聚集率為(32.38±11.38)%,腦梗死組-治療後患者為(43.81±14.40)%,均低于腦梗死組-治療前患者的(57.00±18.96)%。Spearman 相關分析結果顯示,對照組受檢者、腦梗死組-治療前患者、腦梗死組-治療後患者血小闆 NMDA 受體相對錶達量與血小闆聚集率均無直線相關性( P ﹥0.05)。結論腦梗死患者血小闆 NMDA 受體錶達水平升高,阿司匹林可上調腦梗死患者血小闆 NMDA 受體的錶達, NMDA 受體錶達增加可能是腦梗死患者髮生 AR 的重要原因。
목적:탐토뇌경사환자혈소판 N -갑기- D -천동안산(NMDA)수체표체여아사필림저항(AR)적상관성。방법선택2011년8월-2013년7월재아원신경내과주원적뇌경사환자45례위뇌경사조,동기재아원체검중심체검건강자40례위대조조。뇌경사환자학진후즉개시규률복용아사필림(100 mg/ d),검측량조수검자 NMDA 수체표체수평화혈소판취집솔。결과대조조수검자 NMDA 수체상대표체량위(0.11±0.07),저우뇌경사조-치료전환자적(0.32±0.12)(P ﹤0.001),뇌경사조-치료전환자 NMDA 수체상대표체량저우뇌경사조-치료후환자적(0.69±0.15)(P ﹤0.001)。대조조수검자혈소판취집솔위(32.38±11.38)%,뇌경사조-치료후환자위(43.81±14.40)%,균저우뇌경사조-치료전환자적(57.00±18.96)%。Spearman 상관분석결과현시,대조조수검자、뇌경사조-치료전환자、뇌경사조-치료후환자혈소판 NMDA 수체상대표체량여혈소판취집솔균무직선상관성( P ﹥0.05)。결론뇌경사환자혈소판 NMDA 수체표체수평승고,아사필림가상조뇌경사환자혈소판 NMDA 수체적표체, NMDA 수체표체증가가능시뇌경사환자발생 AR 적중요원인。
Objective To investigate the correlation between expression of N - Methyl - D - aspartate(NMDA)re-ceptor of platelets and aspirin resistance in patients with cerebral infarction. Methods From August 2011 to July 2013,a total of 45 patients with cerebral infarction admitted to Department of Neurology of our hospital were selected as case group,while 40 healthy cases in our hospital were selected as control group. Case group given aspirin ( 100 mg per day ) after diag-nosed. Expression of NMDA receptor and rate of platelet aggregation of the two groups were detected. Results The relative ex-pression of NMDA receptor of control group was(0. 11 ± 0. 07),was lower than that of case group of(0. 32 ± 0. 12)(P ﹤0. 001)before treatment,while that of case group before treatment was lower than that of case group of(0. 69 ± 0. 15)(P ﹤0. 001)after treatment. The rate of platelet aggregation of control group was(32. 38 ± 11. 38)% ,that of case group after treat-ment was(43. 81 ± 14. 40)% ,were both lower than that of case group of(57. 00 ± 18. 96)% before treatment. Spearman corre-lation analysis showed that,the relative expression of NMDA receptor of control group,of case group before or after treatment was not correlated with the rate of platelet aggregation(P ﹥ 0. 05). Conclusion The expression of NMDA receptor of platelets in patients with cerebral infarctionis ishigher,aspirin can up - regulated its expression,and increasing of NMDA receptor may play an important role in aspirin resistance.