CAJ | 학술논문

自噬是指细胞内的自身物质被溶酶体所降解的过程，为普遍存在的生命现象，是细胞处于饥饿状态时的一种自我保护机制。既往研究表明，在心肌缺血再灌注过程中，自噬被诱导激活，自噬体明显增多。自噬在缺血再灌注中的作用表现出双面性，缺血期主要发挥保护作用，但再灌注时期自噬过度激活则表现出损伤作用，可导致自噬性细胞死亡。自噬具体是如何被激活，怎样发挥其影响作用，至今尚无清楚的答案。本文就自噬在心肌缺血再灌注中作用的研究进展进行综述。
자서시지세포내적자신물질피용매체소강해적과정，위보편존재적생명현상，시세포처우기아상태시적일충자아보호궤제。기왕연구표명，재심기결혈재관주과정중，자서피유도격활，자서체명현증다。자서재결혈재관주중적작용표현출쌍면성，결혈기주요발휘보호작용，단재관주시기자서과도격활칙표현출손상작용，가도치자서성세포사망。자서구체시여하피격활，즘양발휘기영향작용，지금상무청초적답안。본문취자서재심기결혈재관주중작용적연구진전진행종술。
Autophagy is an activity that cytoplastic components degrading by lysosome,it is a common life phenome-non,and also an important self - protect mechanism of starvation. Previous researches showed that,autophagy was induced and activated by ischemia reperfusion,and autophagosomes increased. Autophagy played a dual role in myocardial ischemia reperfu-sion,including protective effect in ischemic stage and harmful effect in reperfusion period,and excessive activation of autophagy in reperfusion period may cause autophagic cell death. How to activate and how to work in myocardial ischemia reperfusion of auto-phagy is still not clear now. This paper reviewed the research on the role of autophagy in myocardial ischemia reperfusion.