CAJ | 학술논문

目的：观察大动脉粥样硬化性脑梗死患者血浆中溶血磷脂酸（ LPA）的变化及其与临床神经功能障碍的相关性，探讨新的炎性生物学标志物及其与疾病严重程度的关系。方法选取经临床和辅助检查确诊的30例急性期大动脉粥样硬化性患者，测定其血浆LPA水平，并对脑梗死患者进行神经功能缺损评分量表（ NIHSS）评分。结果大动脉粥样硬化性脑梗死患者血浆LPA水平与神经功能缺损程度（ NIHSS评分）呈正相关。结论血浆LPA水平可作为急性大动脉粥样硬化性脑梗死患者疾病活动性的炎性标志物，并可用于评价大动脉粥样硬化性脑梗死的临床神经功能障碍程度。
목적：관찰대동맥죽양경화성뇌경사환자혈장중용혈린지산（ LPA）적변화급기여림상신경공능장애적상관성，탐토신적염성생물학표지물급기여질병엄중정도적관계。방법선취경림상화보조검사학진적30례급성기대동맥죽양경화성환자，측정기혈장LPA수평，병대뇌경사환자진행신경공능결손평분량표（ NIHSS）평분。결과대동맥죽양경화성뇌경사환자혈장LPA수평여신경공능결손정도（ NIHSS평분）정정상관。결론혈장LPA수평가작위급성대동맥죽양경화성뇌경사환자질병활동성적염성표지물，병가용우평개대동맥죽양경화성뇌경사적림상신경공능장애정도。
Objective To observe the plasma level changes of lysophosphatidic acid( LPA)in patients with large artery ath-erosclerotic cerebral infarction and analyze their correlation with the clinical neurological dysfunction,and to investigate the rela-tionship of new inflammatory biomarkers with disease activity. Methods Thirty patients with large artery atherosclerotic cerebral infarction at acute period were chose,and the plasma LPA levels were detected,and neurological dysfunction was evaluated by National Institutes of Health Stroke Scale( NIHSS)score. Results Plasma LPA levels in patients with large artery atherosclerot-ic cerebral infarction were positively correlated with NIHSS score. Conclusion Plasma LPA levels can be used as inflammatory markers for disease activity in patients with large artery atherosclerotic cerebral infarction,and can be used to evaluate the clinical degree of neurological dysfunction in patients with large artery atherosclerotic cerebral infarction.