CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病( COPD)评估测试( CAT评分)与预后因素的相关性,为其临床应用提供依据。方法共纳入2009年1月-2013年9月该院诊断为稳定期COPD患者220例,详细记录患者相关信息,积极给予相应的对症支持治疗措施,于治疗前、治疗后3月行CAT评分,6 min步行试验(6MWT),生活质量评估问卷(mMRC)等,分析其相关关系。结果220例COPD患者中CAT评分轻微影响24例,中等影响95例,严重影响76例,非常严重影响25例。随CAT评分的增加,患者FEV1/FVC、FEV1及6MWT均有明显下降,而吸烟指数及mMRC明显上升,比较差异有统计学意义(P<0.05)；中等影响、严重影响、非常严重影响吸烟指数高于轻微影响,差异有统计学意义(P<0.05),但三者间比较差异不明显(P>0.05)；FEV1/FVC、FEV1、6MWT及mMRC两两比较均有差异(P<0.05)。治疗后FEV1/FVC、FEV1、6MWT、CAT评分与治疗前相比差异均有统计学意义(P<0.05),mMRC比较均无差异(P>0.05)。 CAT评分与FEV1/FVC、FEV1、6MWT呈负相关关系,与mMRC呈正相关关系(P<0.05)。结论 CAT评分可以对COPD患者的生活质量及临床治疗效果进行有效的评估,同时与患者的肺功能,吸烟、耐力及呼吸困难指数等影响患者预后的相关因素存在密切相关性,可作为COPD患者预后评价的指标之一。
목적：탐토만성조새성폐질병( COPD)평고측시( CAT평분)여예후인소적상관성,위기림상응용제공의거。방법공납입2009년1월-2013년9월해원진단위은정기COPD환자220례,상세기록환자상관신식,적겁급여상응적대증지지치료조시,우치료전、치료후3월행CAT평분,6 min보행시험(6MWT),생활질량평고문권(mMRC)등,분석기상관관계。결과220례COPD환자중CAT평분경미영향24례,중등영향95례,엄중영향76례,비상엄중영향25례。수CAT평분적증가,환자FEV1/FVC、FEV1급6MWT균유명현하강,이흡연지수급mMRC명현상승,비교차이유통계학의의(P<0.05)；중등영향、엄중영향、비상엄중영향흡연지수고우경미영향,차이유통계학의의(P<0.05),단삼자간비교차이불명현(P>0.05)；FEV1/FVC、FEV1、6MWT급mMRC량량비교균유차이(P<0.05)。치료후FEV1/FVC、FEV1、6MWT、CAT평분여치료전상비차이균유통계학의의(P<0.05),mMRC비교균무차이(P>0.05)。 CAT평분여FEV1/FVC、FEV1、6MWT정부상관관계,여mMRC정정상관관계(P<0.05)。결론 CAT평분가이대COPD환자적생활질량급림상치료효과진행유효적평고,동시여환자적폐공능,흡연、내력급호흡곤난지수등영향환자예후적상관인소존재밀절상관성,가작위COPD환자예후평개적지표지일。
Objective To explore the relationship between chronic obstructive pulmonary disease(COPD) assessment test score and prognostic factors. Methods Two hundred and twenty patients with COPD diagnosed from January 2009 to September 2013 were in-cluded. All patients were actively given corresponding support measures to treat. CAT scores, 6-minute walk test (6 MWT), quality of life assessment questionnaire ( mMRC) were recorded before and after the treatment. Results Among 220 patients with COPD, slight-ly affected CAT score were 24 cases, moderate impact 95 cases, seriously affected 76 cases, very serious impact 25 cases. With the increase of the CAT scores, FEV1/FVC, FEV1 and 6 MWT in the patients obvious dropped, while smoking index and mMRC rose ob-viously. The differences were statistically significant (P<0. 05). The smoking indexes in medium effect, serious influence, very seri-ous influence were higher than that in slight influence(P<0. 05), but there was no obvious difference(P>0. 05). The differences in FEV1/FVC, FEV1, 6 MWT and mMRC were obvious(P<0. 05). The differences in FEV1/FVC, FEV1, 6 MWT, CAT scores before and after treatment were statistically significant (P<0. 05). There was no difference in mMRC (P>0. 05). There were negative cor-relations between FEV1/FVC, FEV1, 6 MWT and CAT scores, and positive correlation between mMRC and CAT scores (P<0. 05). Conclusions CAT score can assess the quality of life of patients with COPD and clinical therapeutic effect. There are close correla-tions between lung function, smoking, endurance, dyspnea index and CAT score, which can be used as the prognosis evaluation index of patients with COPD.