CAJ | 학술논문

目的：观察自体富血小板凝胶治疗轻、中度眼表烧伤的疗效。方法选取该科收治的眼化学烧伤、热烧伤患者41例(54眼)为研究对象,按照数字随机法分为自体富血小板凝胶治疗组(APG组)和对照组,APG组19例(26眼),对照组22例(28眼)。对照组采用常规局部和全身药物治疗,APG组在此基础上加用自体富血小板凝胶外用滴眼。比较两组患者平均创面的愈合时间、角膜新生血管的发生率及视力恢复情况。结果对照组6眼(21.4%)出现感染,APG组1眼(3.8%)；对照组平均愈合时间为(24.7±6.5) d,APG 组平均愈合时间为(19.1±3.5) d,APG 组平均愈合时间、感染率显著低于对照组(P<0.05)。对照组3个月后各有1眼出现角膜斑翳和角膜云翳,6眼出现角膜新生血管；APG组未出现角膜斑翳和角膜云翳病例,2眼出现角膜新生血管。 APG组角膜新生血管发生率显著低于对照组(P<0.05)。 APG组和对照组治疗后视力均得到不同程度的恢复,两组比较无显著差异(P>0.05)。结论自体富血小板凝胶可缩短眼表修复时间,降低感染率和角膜新生血管发生率,不影响视力恢复,是轻、中度眼表烧伤治疗的新选择。
목적：관찰자체부혈소판응효치료경、중도안표소상적료효。방법선취해과수치적안화학소상、열소상환자41례(54안)위연구대상,안조수자수궤법분위자체부혈소판응효치료조(APG조)화대조조,APG조19례(26안),대조조22례(28안)。대조조채용상규국부화전신약물치료,APG조재차기출상가용자체부혈소판응효외용적안。비교량조환자평균창면적유합시간、각막신생혈관적발생솔급시력회복정황。결과대조조6안(21.4%)출현감염,APG조1안(3.8%)；대조조평균유합시간위(24.7±6.5) d,APG 조평균유합시간위(19.1±3.5) d,APG 조평균유합시간、감염솔현저저우대조조(P<0.05)。대조조3개월후각유1안출현각막반예화각막운예,6안출현각막신생혈관；APG조미출현각막반예화각막운예병례,2안출현각막신생혈관。 APG조각막신생혈관발생솔현저저우대조조(P<0.05)。 APG조화대조조치료후시력균득도불동정도적회복,량조비교무현저차이(P>0.05)。결론자체부혈소판응효가축단안표수복시간,강저감염솔화각막신생혈관발생솔,불영향시력회복,시경、중도안표소상치료적신선택。
Objective To observe the clinical effect of autologous plate-rich gel ( APG) in the treatment of mild and moderate ocular chemical injury and chermal burns. Methods Forty-one patients(54 eyes) with ocular chemical injury and chermal burns were stud-ied,who were randomized into APG group and control group. The control group received regular topical and systemic medication while the APG group received APG outward treatment based on regular topical and systemic medication. Comparison was made in respects of healing time,corneal neovascularization and vision acuity between two groups. Results There were 6 eyes infection and 1 eye infection in control group(21. 4%) and APG group(3. 8%) respectively. The average healing time was (24. 7±6. 5)d and (19. 1±3. 5)d in control group and APG group respectively. The average healing time and infection rate in APG group were lower than control group( P<0. 05). During 3 months,there were 1 eye corneal macula,1 eye corneal nebula,6 eyes ocular neovascularization in control group while 2 eyes ocular neovascularization in APG group. The rates of ocular neovascularization between two groups had obvious differences( P<0. 05). But the vision recovery between two groups had no obvious differences(P>0. 05). Conclusions The application of APG in the treatment of mild and moderate ocular chemical injury and chermal burns could shorten healing time,decrease the rate of infection and ocular neovascularization,and had no impact on vision recovery.