CAJ | 학술논문

目的：探讨制剂辅料对注射用葛根素体外溶血的影响，为临床安全用药提供依据。方法采用改良体外试管法评价注射用葛根素及其制剂辅料对家兔红细胞的溶血作用。结果注射用葛根素可引起家兔红细胞溶血，甘露醇和碳酸氢钠混合液也可以引起家兔红细胞溶血。结论葛根素以及甘露醇和碳酸氢钠之间交互作用可能是引起注射用葛根素溶血的主要原因。
목적：탐토제제보료대주사용갈근소체외용혈적영향，위림상안전용약제공의거。방법채용개량체외시관법평개주사용갈근소급기제제보료대가토홍세포적용혈작용。결과주사용갈근소가인기가토홍세포용혈，감로순화탄산경납혼합액야가이인기가토홍세포용혈。결론갈근소이급감로순화탄산경납지간교호작용가능시인기주사용갈근소용혈적주요원인。
Objective To explore the excipients of puerarin for injection which can cause hemolysis of rabbit erythrocytes and to pro-vide reference for clinical safe drug use. Methods Improved test tube method was used in vitro to evaluate the hemolytic affection of injection component. Results The puerarin for injection could cause hemolysis of rabbit erythrocyte. And the mixture of mannitol and sodium bicarbonate had the same effect. Conclusions The puerarin and the interaction of excipients could be the main causes of he-molysis.