CAJ | 학술논문

目的：评价肝癌术后应用铜绿假单胞菌注射液的疗效。方法选取70例进展期肝癌患者，随机分为两组，肿瘤完整切除后一组患者仅行肝动脉化疗栓塞术（TACE）治疗（对照组），另一组患者行腹腔铜绿假单胞菌注射液灌注＋TACE（治疗组），观察两组肿瘤患者的疗效，包括比较患者肝肾功能、血常规、不良反应和并发症发生情况以及复发转移情况。结果治疗组患者腹腔灌注铜绿假单胞菌注射液前后血清ALT、AST、尿素氮、肌酐及白细胞均无统计学差异（P＞0.05）；治疗组患者肿瘤的复发转移率明显低于对照组，治疗组患者的毒副反应轻微，能自行缓解或者对症处理后缓解。结论对于肝癌患者，腹腔灌注铜绿假单胞菌注射液疗效确切。
목적：평개간암술후응용동록가단포균주사액적료효。방법선취70례진전기간암환자，수궤분위량조，종류완정절제후일조환자부행간동맥화료전새술（TACE）치료（대조조），령일조환자행복강동록가단포균주사액관주＋TACE（치료조），관찰량조종류환자적료효，포괄비교환자간신공능、혈상규、불량반응화병발증발생정황이급복발전이정황。결과치료조환자복강관주동록가단포균주사액전후혈청ALT、AST、뇨소담、기항급백세포균무통계학차이（P＞0.05）；치료조환자종류적복발전이솔명현저우대조조，치료조환자적독부반응경미，능자행완해혹자대증처리후완해。결론대우간암환자，복강관주동록가단포균주사액료효학절。
ObjectiveTo evaluate the efficacy of PA-MSHA injection after liver cancer resection.Methods Seventy cases with advanced primary hepatocellular carcinoma were randomly divided into two groups. After liver cancer resection, patients in TACE group (n=35) were treated with transcatheter arterial chemoembolization(TACE), and patients in combination therapy group (n=35) were treated with TACE together with intraperitoneal injection with PA-MSHA.All patients were followed up for 6-30 months. Postoperative adverse effects and complications were recorded. CT or MRI scanning, AFP level, routine blood test, renal functions and hepatic functions were reexamined.The rate of recurrence and metastasis was calculated. The results were compared between the two groups.Results No significant difference in the hepatic functions(ALT and AST), renal functions (BUN and CRE) and routine blood test (WBC)existed between the two groups (P>0.05). The rate of recurrence and metastasis in combination therapy group was significantly lower than that in simple TACE group (P<0.05). Postoperative adverse effects and complications in combination therapy group which was light can disappear spontaneously or after symptomatic treatment.Conclusion It is a good treatment through intraperitoneal injection with PA-MSHA after liver cancer resection.