中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
24期
41-43
,共3页
维生素B12%多西环素%神经型布氏杆菌病%疗效观察
維生素B12%多西環素%神經型佈氏桿菌病%療效觀察
유생소B12%다서배소%신경형포씨간균병%료효관찰
Vitamin B12%Doxycycline%Neuronal brucellosis%Efficacy
目的：观察维生素B12联合多西环素治疗神经型布氏杆菌病的临床疗效。方法：选取本院门诊及住院患者65例，将其随机分为治疗组35例和对照组30例。治疗组采用维生素B12联合多西环素治疗，对照组单用多西环素治疗，疗程为6周。观察比较两组患者治疗后临床症状、体征好转情况、临床疗效及不良反应发生情况。结果：经过6周的治疗，两组治疗后均好转，在发热和头痛的治疗上差异均无统计学意义（P>0.05），而治疗组在乏力、骨关节痛、脑膜刺激征、手足麻木、面瘫等方面与对照组比较差异均有统计学意义（P<0.05）。治疗组的总有效率94.3%明显高于对照组的66.7%，差异有统计学意义（P<0.05）。两组不良反应情况无明显差异（P>0.05）。结论：维生素B12联合多西环素治疗神经型布氏杆菌病是一种有效的治疗方法，值得在临床上推广。
目的：觀察維生素B12聯閤多西環素治療神經型佈氏桿菌病的臨床療效。方法：選取本院門診及住院患者65例，將其隨機分為治療組35例和對照組30例。治療組採用維生素B12聯閤多西環素治療，對照組單用多西環素治療，療程為6週。觀察比較兩組患者治療後臨床癥狀、體徵好轉情況、臨床療效及不良反應髮生情況。結果：經過6週的治療，兩組治療後均好轉，在髮熱和頭痛的治療上差異均無統計學意義（P>0.05），而治療組在乏力、骨關節痛、腦膜刺激徵、手足痳木、麵癱等方麵與對照組比較差異均有統計學意義（P<0.05）。治療組的總有效率94.3%明顯高于對照組的66.7%，差異有統計學意義（P<0.05）。兩組不良反應情況無明顯差異（P>0.05）。結論：維生素B12聯閤多西環素治療神經型佈氏桿菌病是一種有效的治療方法，值得在臨床上推廣。
목적：관찰유생소B12연합다서배소치료신경형포씨간균병적림상료효。방법：선취본원문진급주원환자65례，장기수궤분위치료조35례화대조조30례。치료조채용유생소B12연합다서배소치료，대조조단용다서배소치료，료정위6주。관찰비교량조환자치료후림상증상、체정호전정황、림상료효급불량반응발생정황。결과：경과6주적치료，량조치료후균호전，재발열화두통적치료상차이균무통계학의의（P>0.05），이치료조재핍력、골관절통、뇌막자격정、수족마목、면탄등방면여대조조비교차이균유통계학의의（P<0.05）。치료조적총유효솔94.3%명현고우대조조적66.7%，차이유통계학의의（P<0.05）。량조불량반응정황무명현차이（P>0.05）。결론：유생소B12연합다서배소치료신경형포씨간균병시일충유효적치료방법，치득재림상상추엄。
Objective:To observe the clinical efficacy of vitamin B12 combined with doxycycline in treatment of neurological brucellosis.Method:65 outpatients and hospitalized patients in our hospital were selected,they were randomly divided into the treatment group for 35 cases and the control group for 30 cases,the treatment group was given vitamin B12 combined with doxycycline,the control group was only given doxycycline treatment,six weeks as a course of treatment.The clinical symptoms,physical signs of improvement,clinical effect and adverse reaction after treatment between the two groups were observed and compared.Result:After six weeks of treatment,the two groups after treatment were improved,the fever and headache treatment showed no significant differences(P>0.05),there were statistically significant differences in the aspect of fatigue,bone and joint pain,meningeal irritation sign,numbness,paralysis between the two groups(P<0.05).The total efficiency of treatment group was 94.3%,it was significantly higher than 66.7%of control group,the difference was statistically significant(P<0.05).There was no significant difference between the two groups in adverse circumstances(P>0.05).Conclusion:Vitamin B12 combined with doxycycline in the treatment of neurobrucellosis is an effective method of treatment,is worthy of clinical promotion.
