CAJ | 학술논문

目的：观察冠状动脉内支架成形术治疗冠心病患者手术前后血清slox-1、hs-CRP的变化，以及术后使用麝香保心丸对其的影响。方法：收治冠心病冠状动脉内支架成形术后患者64例，随机分为治疗组(术后24小时在常规治疗基础上加用麝香保心丸)32例和对照组(仅常规治疗)32例，治疗8周。分别采用酶联免疫法和免疫浊度法动态检测不同时间点患者血清 slox-1、hs-CRP 含量。结果：两组术后血清 hs-CRP 含量显著升高(P＜0.05)；术后8周治疗组hs-CRP显著降低(P＜0.001)，与对照组相比较差异有统计学意义(P＜0.001)。两组术后血清slox-1水平均显著高于术前(P＜0.05)，治疗组血清slox-1水平明显下降(P＜0.001)，也低于对照组8周后水平(P＜0.05)。结论：冠状动脉内支架植入术可致血清 slox-1、hs-CRP 升高，麝香保心丸可降低血清 slox-1、hs-CRP 水平，具有抗炎、稳定动脉粥样硬化斑块的作用。
목적：관찰관상동맥내지가성형술치료관심병환자수술전후혈청slox-1、hs-CRP적변화，이급술후사용사향보심환대기적영향。방법：수치관심병관상동맥내지가성형술후환자64례，수궤분위치료조(술후24소시재상규치료기출상가용사향보심환)32례화대조조(부상규치료)32례，치료8주。분별채용매련면역법화면역탁도법동태검측불동시간점환자혈청 slox-1、hs-CRP 함량。결과：량조술후혈청 hs-CRP 함량현저승고(P＜0.05)；술후8주치료조hs-CRP현저강저(P＜0.001)，여대조조상비교차이유통계학의의(P＜0.001)。량조술후혈청slox-1수평균현저고우술전(P＜0.05)，치료조혈청slox-1수평명현하강(P＜0.001)，야저우대조조8주후수평(P＜0.05)。결론：관상동맥내지가식입술가치혈청 slox-1、hs-CRP 승고，사향보심환가강저혈청 slox-1、hs-CRP 수평，구유항염、은정동맥죽양경화반괴적작용。
Objective:To observe the changes of serum sLOX-1,hs-CRP in patients with coronary heart disease before and after coronary artery stent angioplasty,and the effect of Shexiangbaoxin pill on it.Methods:64 cases treated with coronary artery stent implantation were selected.They were randomly divided into the treatment group(Shexiangbaoxin pill were given 24 hours after the operation on the basis of conventional therapy) and the control group(only using conventional therapy) with 32 cases in each.Both groups were treated for 8 weeks.The content of serum sLOX-1 and hs-CRP in patients were dynamicly detected at different time points using ELISA and immune nephelometry respectively.Results:After operation,the content of serum hs-CRP increased significantly in two groups(P<0.05);after 8 weeks the content of hs-CRP decreased significantly in the treatment group(P<0.001).When compared with the control group,the difference was statistically significant(P<0.001).The levels of serum sLOX-1 after operation were significantly higher than those before operation in two groups(P<0.05).The level of serum sLOX-1 decreased significantly in the treatment group(P<0.001),and lower than that of the control group after 8 weeks(P<0.05).Conclusion:Coronary artery stent implantation can increase serum sLOX-1 and hs-CRP.Shexiangbaoxin pills could reduce the contents of serum sLOX-1 and hs-CRP.It has the effect of anti-inflammatory and stability of atherosclerotic plaque.