波谱学杂志
波譜學雜誌
파보학잡지
CHINESE JOURNAL OF MAGNETIC RESONANCE
2014年
3期
426-436
,共11页
孙麒%杨庆昆%龚珊珊%马茶
孫麒%楊慶昆%龔珊珊%馬茶
손기%양경곤%공산산%마다
磷氨米酮(Phosphoramidon)%结构确认%1D NMR%2D NMR%端位构型
燐氨米酮(Phosphoramidon)%結構確認%1D NMR%2D NMR%耑位構型
린안미동(Phosphoramidon)%결구학인%1D NMR%2D NMR%단위구형
phosphoramidon%structural elucidation%one-dimensional NMR%two-dimensional NMR%anomeric configuration
磷氨米酮是从链霉菌培养液中分离得到的一种天然磷酰糖肽。作为多种金属蛋白酶的抑制剂，磷氨米酮在生物和医学领域有着广泛的应用。该研究通过对化学合成磷氨米酮及其β-端位异构体的1D NMR波谱(1H，13C和31P NMR)和2D NMR波谱(1H-1H COSY， HSQC和NOESY)的解析，对其NMR信号进行了全归属，并确认了磷氨米酮及其β-端位异构体的端位构型。
燐氨米酮是從鏈黴菌培養液中分離得到的一種天然燐酰糖肽。作為多種金屬蛋白酶的抑製劑，燐氨米酮在生物和醫學領域有著廣汎的應用。該研究通過對化學閤成燐氨米酮及其β-耑位異構體的1D NMR波譜(1H，13C和31P NMR)和2D NMR波譜(1H-1H COSY， HSQC和NOESY)的解析，對其NMR信號進行瞭全歸屬，併確認瞭燐氨米酮及其β-耑位異構體的耑位構型。
린안미동시종련매균배양액중분리득도적일충천연린선당태。작위다충금속단백매적억제제，린안미동재생물화의학영역유착엄범적응용。해연구통과대화학합성린안미동급기β-단위이구체적1D NMR파보(1H，13C화31P NMR)화2D NMR파보(1H-1H COSY， HSQC화NOESY)적해석，대기NMR신호진행료전귀속，병학인료린안미동급기β-단위이구체적단위구형。
Phosphoramidon is a naturally occurring glycopeptide isolated from the culture of Streptomyces tanashiensis. As an inhibitor of metalloproteases, phosphoramidon has many important applications in biological and medicinal research. On the basis of one-dimensional (i.e., 1H, 13C, and 31P) and two-dimensional (i.e., 1H-1H COSY, HSQC, and NOESY) NMR spectral data, the NMR signals for phosphoramidon and itsb-anomer were assigned. The anomeric configurations of the two isomers were determined.
