CAJ | 학술논문

在过去20多年中,科学家们对磷脂酰肌醇3激酶(phosphoinositide 3-kinase,PI3K)信号通路的研究取得了长足进步.不仅发现了许多特异性的PI3K信号通路抑制剂,而且还证明了许多抑制剂可能对呼吸系统疾病的治疗有良好作用.在本文中,我们通过简要介绍PI3K信号的各种异构体,重点探讨利用这些PI3K异构体作为药物靶点的分子来治疗呼吸系统疾病的现状和前景.例如,科学家们已经能够通过抑制PI3Kα治疗肺癌,抑制PI3Kβ治疗肺动脉高压,而PI3Kδ以及PI3 Kγ在气道炎症性疾病中的研究也有突破.最后,我们还将简要分析PI3K抑制剂治疗呼吸系统相关疾病的前景和展望.
재과거20다년중,과학가문대린지선기순3격매(phosphoinositide 3-kinase,PI3K)신호통로적연구취득료장족진보.불부발현료허다특이성적PI3K신호통로억제제,이차환증명료허다억제제 가능대호흡계통질병적치료유량호작용.재본문중,아문통과간요개소PI3K신호적각충이구체,중점탐토이용저사PI3K이구체작위약물파점적분자래치료호흡계통질병적현상화전경.례여,과학가문이경능구통과억제PI3Kα치료폐암,억제PI3Kβ치료폐동맥고압,이PI3Kδ이급PI3 Kγ재기도염증성질병중적연구야유돌파.최후,아문환장간요분석PI3K억제제치료호흡계통상관질병적전경화전망.
In the past decades,scientists have made lots of progress in the deep understanding of phosphoinositide 3-kinase (PI3K) signaling.Many specific inhibitors of PI3K signaling have been found,and some studies have been proved to have effects in the therapy of respiratory diseases.Here,we introduce the isoforms of PI3Ks firstly,and focus on the assessment of each isoform as a drug discovery target in respiratory diseases.The application of PI3Kα inhibition in the treatment of lung cancer,PI3Kβ inhibitors in pulmonary arterial hypertension,PI3Kδ and PI3Kγ inhibitors in airway inflammatory diseases are well studied.We also discuss the future of PI3K inhibitors in respiratory disease.