国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
4期
215-217
,共3页
湿疹%青鹏软膏%香料%过敏反应
濕疹%青鵬軟膏%香料%過敏反應
습진%청붕연고%향료%과민반응
Eczema%Qingpeng ointment%Perfume%Anaphylaxis
目的 通过调查两种香精标志物芳香混合物和松香斑贴试验阳性的患者对青鹏软膏的斑贴试验结果及临床相关性,探讨临床上芳香混合物和松香过敏患者可否安全使用青鹏软膏.方法 使用青鹏软膏原物及欧洲标准变应原系列对门诊湿疹皮炎患者进行斑贴试验及随访,采用病史回顾及随访的方法,确定斑贴试验结果的相关性.应用SPSS 17.0进行数据处理和分析,计数资料描述其构成比,组间率的比较采用卡方检验或Fisher精确检验.结果 333例患者为连续入组,其中男48例,女285例,年龄14～77岁,平均(35.9土13.5)岁.芳香混合物及松香斑贴阳性率分别为3.8％和2.7％.青鹏软膏斑贴试验阳性者仅5例(1.5％),均无临床相关性.芳香混合物及松香斑贴试验阳性者与阴性者中青鹏软膏斑贴试验阳性率分别为5.9％及1.6％,差异无统计学意义(P＞0.05).结论 湿疹患者香精过敏常见,但青鹏软膏的斑贴试验阳性率为1.5％,且无临床相关性;芳香混合物和松香是否过敏与青鹏软膏斑贴试验是否阳性未见相关性,值得进一步研究.
目的 通過調查兩種香精標誌物芳香混閤物和鬆香斑貼試驗暘性的患者對青鵬軟膏的斑貼試驗結果及臨床相關性,探討臨床上芳香混閤物和鬆香過敏患者可否安全使用青鵬軟膏.方法 使用青鵬軟膏原物及歐洲標準變應原繫列對門診濕疹皮炎患者進行斑貼試驗及隨訪,採用病史迴顧及隨訪的方法,確定斑貼試驗結果的相關性.應用SPSS 17.0進行數據處理和分析,計數資料描述其構成比,組間率的比較採用卡方檢驗或Fisher精確檢驗.結果 333例患者為連續入組,其中男48例,女285例,年齡14～77歲,平均(35.9土13.5)歲.芳香混閤物及鬆香斑貼暘性率分彆為3.8％和2.7％.青鵬軟膏斑貼試驗暘性者僅5例(1.5％),均無臨床相關性.芳香混閤物及鬆香斑貼試驗暘性者與陰性者中青鵬軟膏斑貼試驗暘性率分彆為5.9％及1.6％,差異無統計學意義(P＞0.05).結論 濕疹患者香精過敏常見,但青鵬軟膏的斑貼試驗暘性率為1.5％,且無臨床相關性;芳香混閤物和鬆香是否過敏與青鵬軟膏斑貼試驗是否暘性未見相關性,值得進一步研究.
목적 통과조사량충향정표지물방향혼합물화송향반첩시험양성적환자대청붕연고적반첩시험결과급림상상관성,탐토림상상방향혼합물화송향과민환자가부안전사용청붕연고.방법 사용청붕연고원물급구주표준변응원계렬대문진습진피염환자진행반첩시험급수방,채용병사회고급수방적방법,학정반첩시험결과적상관성.응용SPSS 17.0진행수거처리화분석,계수자료묘술기구성비,조간솔적비교채용잡방검험혹Fisher정학검험.결과 333례환자위련속입조,기중남48례,녀285례,년령14～77세,평균(35.9토13.5)세.방향혼합물급송향반첩양성솔분별위3.8％화2.7％.청붕연고반첩시험양성자부5례(1.5％),균무림상상관성.방향혼합물급송향반첩시험양성자여음성자중청붕연고반첩시험양성솔분별위5.9％급1.6％,차이무통계학의의(P＞0.05).결론 습진환자향정과민상견,단청붕연고적반첩시험양성솔위1.5％,차무림상상관성;방향혼합물화송향시부과민여청붕연고반첩시험시부양성미견상관성,치득진일보연구.
Objective To evaluate the sensitivity to fragrance mixture,colophony and Qingpeng ointment in patients with eczema by a patch test,and to assess the relationship between patch test reactions to fragrance mixture or colophony and those to Qingpeng ointment,so as to determine if patients clinically reactive to fragrance mixture and colophony can apply Qingpeng ointment safely.Methods Patch testing was carried out with European standard series and raw materials of Qingpeng ointment in outpatients with eczema or dermatitis.The clinical relevance of patch test results was analyzed based on clinical medical history and a follow-up study.Data were processed with the SPSS 17.0 software.Constituent ratio was used for statistical description,and intergroup comparison was carried out by chi-square test and Fisher's exact test.Results Totally,333 patients (including 48 males and 285 females) were consecutively enrolled in this study,with an average age of 35.9 years (range,14-77 years).The positivity rate of patch test with fragrance and colophony was 3.8％ and 2.7％ respectively.Five (1.5％) patients showed positive patch test reactions to Qingpeng ointment but no clinical relevance was identified.No significant difference was observed in the positivity rate of patch test with Qingpeng ointment between patients with positive patch test reactions to fragrance mix or colophony and those without (5.9％ vs.1.6％,Fisher's exact test,P ＞ 0.05).Conclusions Fragrance allergy is common in patients with eczema,but the positivity rate of patch test with Qingpeng ointment is low (1.5％) with no clinical relevance.No association is found between the allergy to fragrance mixture and colophony and that to Qingpeng ointment,which deserves further study.
