CAJ | 학술논문

制备胰岛素/油酸钠复合物，对其制备工艺进行考察，提高胰岛素在水中的表观油水分配系数，以期进行进一步的制剂研究。采用非水离子对法制备胰岛素/油酸钠复合物，并以单因素考察优化制备工艺，对复合物进行红外分析，考察胰岛素表观油水分配系数的变化。胰岛素/油酸钠复合物的制备工艺为：油酸钠与胰岛素摩尔比为6∶1，室温下磁力搅拌（500 rpm ）0.5 h。按照此方法成功制备了胰岛素/油酸钠复合物，复合物在水中的油水分布系数得到明显的提高。
제비이도소/유산납복합물，대기제비공예진행고찰，제고이도소재수중적표관유수분배계수，이기진행진일보적제제연구。채용비수리자대법제비이도소/유산납복합물，병이단인소고찰우화제비공예，대복합물진행홍외분석，고찰이도소표관유수분배계수적변화。이도소/유산납복합물적제비공예위：유산납여이도소마이비위6∶1，실온하자력교반（500 rpm ）0.5 h。안조차방법성공제비료이도소/유산납복합물，복합물재수중적유수분포계수득도명현적제고。
To improve apparent partition coefficient by preparing Insulin/sodium oleate (Insulin/S.O ) complex .Insulin/S.O complex was prepared by hydrophobic ion pairing (HIP) method .The effects of many factors including molar ratio of S.O to insulin , reaction temperature , reaction time and rate of rotation were studied to get optimized process ,then the apparent partition coefficient of insulin and FITR analysis were studied to confirm the formation of Insulin/S.O complex . The optimized preparation conditions were determined as follows :the molar ratio of S.O to insulin ,the reaction temperature ,the rate of rotation and the reaction time were 6∶1 ,ambient temperature ,500 rpm and 0.5 h ,respectively . Insulin/S.O complex can be made by HIP method and the apparent partition coefficient of insulin can be evidently improved by the method .