CAJ | 학술논문

磁共振成像(MRI)技术具有非侵入、无放射性的特点，在临床疾病诊断中具有独特的优势，但是肺部空腔的特殊结构使传统质子 MRI无法对其直接成像。自旋交换光抽运(SEOP)方法可以使惰性气体原子的极化度增强4个量级以上，从而使肺部的气体MRI成为可能。该文介绍了超极化惰性气体肺部MRI的最新研究进展，包括超极化气体磁共振相关参数的测量方法、肺部通气结构成像、肺部气体交换功能成像，同时比较了常用于肺部MRI气体的优点和缺点。
자공진성상(MRI)기술구유비침입、무방사성적특점，재림상질병진단중구유독특적우세，단시폐부공강적특수결구사전통질자 MRI무법대기직접성상。자선교환광추운(SEOP)방법가이사타성기체원자적겁화도증강4개량급이상，종이사폐부적기체MRI성위가능。해문개소료초겁화타성기체폐부MRI적최신연구진전，포괄초겁화기체자공진상관삼수적측량방법、폐부통기결구성상、폐부기체교환공능성상，동시비교료상용우폐부MRI기체적우점화결점。
Magnetic resonance imaging (MRI) is a nonradioactive and noninvasive medical imaging technique, and it has been widely applied in the clinical diagnosis. However, using conventional proton MRI to obtain lung images is difficult, because the proton density in the lungs is about three orders of magnitude lower than that in other organs/tissues due to air cavities in the lungs. Hyperpolarized noble gases can be used as contrast agents for lung MRI. Spin-exchange optical pumping (SEOP) is a technique that can be used to enhance the nuclear spin polarizations of noble gases more than 10 000 folds, which makes noble gas lung MRI feasible. In this paper, the recent developments of hyperpolarized gases lung MRI were reviewed. Topics covered include comparison of different hyperpolarized noble gases used for lung MRI, unconventional methods for measuring quantitative parameters in hyperpolarized gas MRI, and the most updated applications of hyperpolarized gas MRI in assessing pulmonary structure and function.