CAJ | 학술논문

目的探讨非酒精性脂肪肝（NAFLD ）对2型糖尿病患者左室舒张功能的影响。方法纳入596例2型糖尿病住院患者，进行腹部超声、颈动脉超声、心脏超声等检查，以E/A作为评估左室舒张功能的指标，分为NAFLD组和非NAFLD组，组内或组间差异比较用单因素方差分析或χ2检验，并采用多因素Logistic回归分析对可能影响舒张功能的因素进行分析。结果2型糖尿病合并NAFLD组的BMI、收缩压、丙氨酸氨基转移酶、甘油三酯、LDL胆固醇、HbA1c、HOMA IR、颈动脉内膜中层厚度显著高于无NAFLD组（P＜0.05），E/A值显著低于无NAFLD组（P＜0.05）；NAFLD与左室舒张功能减退的相关性经多因素Logistic回归分析进行校正后OR值为1.72（95％ CI 1.26～2.75，P＜0.05）。结论在2型糖尿病患者中，NAFLD是左室舒张功能减退的重要危险因素。
목적탐토비주정성지방간（NAFLD ）대2형당뇨병환자좌실서장공능적영향。방법납입596례2형당뇨병주원환자，진행복부초성、경동맥초성、심장초성등검사，이E/A작위평고좌실서장공능적지표，분위NAFLD조화비NAFLD조，조내혹조간차이비교용단인소방차분석혹χ2검험，병채용다인소Logistic회귀분석대가능영향서장공능적인소진행분석。결과2형당뇨병합병NAFLD조적BMI、수축압、병안산안기전이매、감유삼지、LDL담고순、HbA1c、HOMA IR、경동맥내막중층후도현저고우무NAFLD조（P＜0.05），E/A치현저저우무NAFLD조（P＜0.05）；NAFLD여좌실서장공능감퇴적상관성경다인소Logistic회귀분석진행교정후OR치위1.72（95％ CI 1.26～2.75，P＜0.05）。결론재2형당뇨병환자중，NAFLD시좌실서장공능감퇴적중요위험인소。
ObjectiveToevaluatetheinfluenceofnon alcoholicfattyliverdisease(NAFLD)onleftdiastolicventricularfunctionin type 2 diabetes patients .Methods The type 2 diabetic patients were enrolled (n=596) ,tests like abdomen ultrasound ,carotid artery ultrasound ,cardiac uhrasonography were cawied out .E/A was used as an index to evaluate the left ventricular diastolic dysfunction , andpatientsweredividedintoNAFLDgroupandnon NAFLDgroup.Usingone wayANOVAorchi squaretestasamethodtoanalyze thedifferencesbetweentwogroups.Usingmulti factorLogisticregressionanalysistoanalyzethefactorsthatmayinfluencetheleft ventricular diastolic function . P< 0 .05 considered statistically significant .Results Body mass index , systolic pressure , alanine aminotransferase , triglyceride , low density lipoprotein cholesterin , HbA1c , homeostasis model assessment of insulin resistance (HOMA IR),intima mediathickness(IMT)weresignificantlyhigherinindividualswithNAFLDthaninthosewithoutNAFLD(P<0 .05) .Patients with NAFLD had a remarkably lower E/A(0 .82 ± 0 .18 , P<0 .05) .NAFLD remained independently associated with left ventricular dysfunction in multivariate logistic regression analysis (Odds Ratio 1 .72 ,95% CI 1 .26~2 .75 , P<0 .05 ) . Conclusions NAFLD is an independent risk factor of decline of left ventricle diastole function in type 2 diabetes patients .