心脑血管病防治
心腦血管病防治
심뇌혈관병방치
PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
2014年
4期
284-286
,共3页
冠心病%血清铁蛋白%血浆同型半胱氨酸
冠心病%血清鐵蛋白%血漿同型半胱氨痠
관심병%혈청철단백%혈장동형반광안산
Coronary heart disease%Serum ferritin%Homocysteine
目的探讨血清铁蛋白（SF ）和血浆同型半胱氨酸（Hcy ）水平对冠心病（CHD ）及病变类型的预测价值。方法选择行冠状动脉造影的患者145例，根据造影结果分为冠心病组（CHD组）和非冠心病（NCHD ）组；CHD组根据动脉病变类型分为单支、双支和三支病变组测定SF、Hcy和血脂水平，进行统计学分析。结果 CHD组SF和Hcy水平显著高于NCHD组（ P＜0.01），不同动脉病变组SF水平均高于NCHD组（ P＜0.01）。除单支病变组与NCHD组比较Hcy差异无统计学意义外，其余病变组Hcy水平均高于NCHD组（ P＜0.05）。SF与CHD的发病密切相关（OR＝1.01，P＜0.01）。SF预测CHD的ROC曲线下面积为0.83，95％的可信区间为0.76～0.89（ P＜0.01），Hcy预测CHD的ROC曲线下面积为0.64，95％的可信区间为0.55～0.73（ P＜0.01）。结论 SF升高是CHD的另一独立危险因素，CHD患者的Hcy较NCHD组高，测定血浆SF和Hcy的水平对CHD的预测有一定临床意义。
目的探討血清鐵蛋白（SF ）和血漿同型半胱氨痠（Hcy ）水平對冠心病（CHD ）及病變類型的預測價值。方法選擇行冠狀動脈造影的患者145例，根據造影結果分為冠心病組（CHD組）和非冠心病（NCHD ）組；CHD組根據動脈病變類型分為單支、雙支和三支病變組測定SF、Hcy和血脂水平，進行統計學分析。結果 CHD組SF和Hcy水平顯著高于NCHD組（ P＜0.01），不同動脈病變組SF水平均高于NCHD組（ P＜0.01）。除單支病變組與NCHD組比較Hcy差異無統計學意義外，其餘病變組Hcy水平均高于NCHD組（ P＜0.05）。SF與CHD的髮病密切相關（OR＝1.01，P＜0.01）。SF預測CHD的ROC麯線下麵積為0.83，95％的可信區間為0.76～0.89（ P＜0.01），Hcy預測CHD的ROC麯線下麵積為0.64，95％的可信區間為0.55～0.73（ P＜0.01）。結論 SF升高是CHD的另一獨立危險因素，CHD患者的Hcy較NCHD組高，測定血漿SF和Hcy的水平對CHD的預測有一定臨床意義。
목적탐토혈청철단백（SF ）화혈장동형반광안산（Hcy ）수평대관심병（CHD ）급병변류형적예측개치。방법선택행관상동맥조영적환자145례，근거조영결과분위관심병조（CHD조）화비관심병（NCHD ）조；CHD조근거동맥병변류형분위단지、쌍지화삼지병변조측정SF、Hcy화혈지수평，진행통계학분석。결과 CHD조SF화Hcy수평현저고우NCHD조（ P＜0.01），불동동맥병변조SF수평균고우NCHD조（ P＜0.01）。제단지병변조여NCHD조비교Hcy차이무통계학의의외，기여병변조Hcy수평균고우NCHD조（ P＜0.05）。SF여CHD적발병밀절상관（OR＝1.01，P＜0.01）。SF예측CHD적ROC곡선하면적위0.83，95％적가신구간위0.76～0.89（ P＜0.01），Hcy예측CHD적ROC곡선하면적위0.64，95％적가신구간위0.55～0.73（ P＜0.01）。결론 SF승고시CHD적령일독립위험인소，CHD환자적Hcy교NCHD조고，측정혈장SF화Hcy적수평대CHD적예측유일정림상의의。
Objective To discuss the predictive value of homocysteine and serum ferritin (SF) for coronary heart disease .Methods 145patientsunderwentcoronaryangiographywereenrolledanddividedintoCHDgroupandthenone CHD(NCHD)groupbythere-sults .The CHD group were divided into single branch group ,two branches group and three branches group according to the types of arterialdisease.SF,Hcyandblood lipoidsweredetected,andthenprocessedstatisticalanalysis.ResultsCHDgrouphadhigher concentrationofSFandHcythannone CHDgroup(P<0.01).ThetwoandthreebranchesgroupshadhigherlevelofSFandHcy than NCHDgroup ( P<0 .05) ,while the single branch group had only statistically different in SF compared to NCHD group .SF had a close correlation with CHD (OR=1 .01 , P<0 .01) .Furthermore ,receiver operating characteristic (ROC) curves were used to analyze the ability of SF and Hcy to discriminate CHD .The area under ROC curves of SF predicting CHD was 0 .826 (95% confi-dence interval=0 .760~0 .892 , P<0 .01 ) as well as Hcy was 0 .644 (95% confidence interval=0 .554~0 .734 , P<0 .01 ) . Conclusions SF is another important risk factor of CHD .Patients with CHD always have high level of Hcy .These results suggest that measurement of SF and Hcy could be of great assistance in predicating CHD .
