CAJ | 학술논문

研究人工悬浮培养的发菜胞外多糖对小鼠非特异性及特异性免疫能力的影响．体内实验表明：50～100,mg/(kg·d)的发菜胞外多糖能够显著提高小鼠单核巨噬细胞吞噬碳粒的能力和 NK 细胞的自然杀伤活性(P＜0.05)，并呈现剂量依赖性，同时，发菜胞外多糖能在一定程度上提高腹腔巨噬细胞的吞噬能力，起到提高机体非特异性免疫水平的作用．与空白组相比，高、低剂量的发菜胞外多糖对小鼠脏器指数、二硝基氟苯诱导的迟发型超敏反应(DTH)、脾淋巴细胞的增殖均无显著性影响，表明人工培养发菜胞外多糖对小鼠特异性免疫系统无显著性效果．
연구인공현부배양적발채포외다당대소서비특이성급특이성면역능력적영향．체내실험표명：50～100,mg/(kg·d)적발채포외다당능구현저제고소서단핵거서세포탄서탄립적능력화 NK 세포적자연살상활성(P＜0.05)，병정현제량의뢰성，동시，발채포외다당능재일정정도상제고복강거서세포적탄서능력，기도제고궤체비특이성면역수평적작용．여공백조상비，고、저제량적발채포외다당대소서장기지수、이초기불분유도적지발형초민반응(DTH)、비림파세포적증식균무현저성영향，표명인공배양발채포외다당대소서특이성면역계통무현저성효과．
The effect of extracellular polysaccharides(EPS)from liquid-cultured Nostoc flagelliforme on the specific and non-specific immune abilities of mice has been investigated. It was found that the phagocytic index of carbon granular clear-ance and the activity of NK cells increased significantly(P<0.05)in a dosage dependent manner in the range of 50-100,mg/(kg·d). The phagocytic ability of the peritoneal macrophages was also improved to some extend. All this indicated EPS could promote the non-specific immunity effectively. The organism indexes in mice,the delayed-type hypersensitiv-ity(DTH)induced by dinitrofluorobenzene and the proliferation of lymphocytes in the low and high doses of EPS showed no significant difference compared with those of the control group,which suggested that EPS from liquid-cultured Nostoc flageliforme has a little effect on the specific immune abilities of mice.