CAJ | 학술논문

单核苷酸多态性是随着人类基因组计划的实施发展起来的新一代遗传标记，被认为是疾病易感性和药物反应的决定性因素。研究肿瘤单核苷酸多态性有利于肿瘤易感性及其个体化治疗方案的研究，下一代测序技术的出现使单核苷酸多态性的检测更加快捷简便。本文就下一代测序技术及其在肿瘤单核苷酸多态性等方面的应用进行综述。
단핵감산다태성시수착인류기인조계화적실시발전기래적신일대유전표기，피인위시질병역감성화약물반응적결정성인소。연구종류단핵감산다태성유리우종류역감성급기개체화치료방안적연구，하일대측서기술적출현사단핵감산다태성적검측경가쾌첩간편。본문취하일대측서기술급기재종류단핵감산다태성등방면적응용진행종술。
Early detection and individualized treatment are the keys for the current tumor research. Single nucleotide polymorphism(SNP) is a new generation of genetic marker along with implementation of the human genome project, which is regarded as the decisive factor of disease susceptibility and drug response. The research on tumor SNP contributes to identification of tumor susceptibility and individualized treatment. Next-generation sequencing technology( NGS) makes it much easier to detect tumor SNP. This is a review on the recent research of NGS and its application on tumor SNP .