CAJ | 학술논문

目的：观察乏氧诱导因子-1α( HIF-1α)在鼻咽癌细胞中的表达情况及其与预后的关系。方法通过治疗前检测200例鼻咽癌患者HIF-1α的表达情况,并分析阳性、阴性表达组治疗疗效来研究其与鼻咽癌预后的关系。结果200例鼻咽癌患者中 HIF-1α表达阳性者151例(75.5%),表达阴性者49例(24．5%)。Ⅰ、Ⅱ期表达阴性、阳性患者的疗效比较差异无统计学意义。Ⅲ~Ⅳa期患者表达阳性者的完全缓解率(85.9%、80.4%)低于表达阴性者(91.7%、84.6%),差异有统计学意义( P=0.032, P=0．041),2年局控率表达阳性者(74.6%、69.6%)低于表达阴性者(87.5%、76.9%),差异有统计学意义(P=0.021、P=0.035),2年生存率表达阳性者(84.5%、76.1%)低于表达阴性患者(95.8%、84.6%),差异有统计学意义( P=0．037、P=0.042)。结论大部分鼻咽癌患者呈现HIF-1α表达阳性,对于Ⅲ~Ⅳa期患者HIF-1α表达阳性与不良预后相关。
목적：관찰핍양유도인자-1α( HIF-1α)재비인암세포중적표체정황급기여예후적관계。방법통과치료전검측200례비인암환자HIF-1α적표체정황,병분석양성、음성표체조치료료효래연구기여비인암예후적관계。결과200례비인암환자중 HIF-1α표체양성자151례(75.5%),표체음성자49례(24．5%)。Ⅰ、Ⅱ기표체음성、양성환자적료효비교차이무통계학의의。Ⅲ~Ⅳa기환자표체양성자적완전완해솔(85.9%、80.4%)저우표체음성자(91.7%、84.6%),차이유통계학의의( P=0.032, P=0．041),2년국공솔표체양성자(74.6%、69.6%)저우표체음성자(87.5%、76.9%),차이유통계학의의(P=0.021、P=0.035),2년생존솔표체양성자(84.5%、76.1%)저우표체음성환자(95.8%、84.6%),차이유통계학의의( P=0．037、P=0.042)。결론대부분비인암환자정현HIF-1α표체양성,대우Ⅲ~Ⅳa기환자HIF-1α표체양성여불량예후상관。
Objective To evaluate the expression of hypoxia-inducible factor-1 alpha ( HIF-1α) in nasopharyngeal cancer cells and its relationship with disease prognosis. Methods 200 patients with nasopharyngeal carcinoma( NPC) in our hospital were collected. The expression of HIF-1αwas detected by immunohistochemistry. The relationship of the HIF-1α expression with disease prognosis was analyzed. Results The number of HIF-1α positive expression was 151 cases ( 75. 5%) , and the number of HIF-1αnegative expression was 49 cases ( 24. 5%) . For stage Ⅰ and Ⅱ patients, the curative effects was no difference between HIF-1α positive and negative expression groups. For stage Ⅲ and Ⅳa patients, the complete tumor regression rate in HIF-1α positive and negative expression groups after treatment was (85. 9%and 80.4%) and(91.7%and 84.6%),respectively,and the difference was statistically significant. The local control rate after 2 years of treatment in HIF-1α positive group ( 74. 6% and 69. 6%) was significantly lower than HIF-1α negative expression group(87.5% and 76.9%). The survival rate after 2 years of treatment in HIF-1α positive expression group ( 84. 5% and 76. 1%) was significantly lower than HIF-1αnegative expression group(95.8%and 84.6%). Conclusion HIF-1αis positively expressed in most of NPC,which is correlated with poor prognosis of stage Ⅲ and Ⅳa patients.