实用医技杂志
實用醫技雜誌
실용의기잡지
JOURNAL OF PRACTICAL MEDICAL TECHNIQUES
2014年
8期
822-826
,共5页
惊厥, 发热性%脑电波%磷酸丙酮酸水合酶%创伤, 神经系统
驚厥, 髮熱性%腦電波%燐痠丙酮痠水閤酶%創傷, 神經繫統
량궐, 발열성%뇌전파%린산병동산수합매%창상, 신경계통
Seizures,febrile%Brain waves%Phosphopyruvate hydratase%Trauma,nervous system
目的:测定热性惊厥(FS)患儿血清中神经元特异性烯醇化酶(NSE)水平与脑电图(EEG)变化,观察NSE 与脑损伤的关系,以便指导临床治疗和改善预后。方法选择 FS 组患儿208例,其中单纯性热性惊厥(SFS)166例,复杂性热性惊厥(CFS)42例,对照组为112名同期我院健康查体儿童。 FS 组患儿于惊厥发作后24 h 内抽取静脉血采用电化学发光法检测血清 NSE,对照组标本留取及处理方法相同。 FS 组患儿分别于发病后第1天和第14天进行 EEG 检查。结果 FS 组患儿血清中 NSE 水平明显高于健康对照组(P<0.01);CFS 组与健康对照组和 SFS 组比较差异均具有统计学意义(P<0.01)。 FS 组患儿惊厥发作后第1天 EEG 异常率为79.8%,其中 SFS 组78.3%,CFS 组85.7%,差异无统计学意义(P>0.05);第14天 EEG 异常率为24.0%,SFS 组仅16.3%,CFS 组则54.8%,2组比较差异具有统计学意义(P<0.01)。结论 FS 后及时测定血清 NSE 水平,并结合 EEG 检查对判断脑损伤程度及预后具有重要价值。
目的:測定熱性驚厥(FS)患兒血清中神經元特異性烯醇化酶(NSE)水平與腦電圖(EEG)變化,觀察NSE 與腦損傷的關繫,以便指導臨床治療和改善預後。方法選擇 FS 組患兒208例,其中單純性熱性驚厥(SFS)166例,複雜性熱性驚厥(CFS)42例,對照組為112名同期我院健康查體兒童。 FS 組患兒于驚厥髮作後24 h 內抽取靜脈血採用電化學髮光法檢測血清 NSE,對照組標本留取及處理方法相同。 FS 組患兒分彆于髮病後第1天和第14天進行 EEG 檢查。結果 FS 組患兒血清中 NSE 水平明顯高于健康對照組(P<0.01);CFS 組與健康對照組和 SFS 組比較差異均具有統計學意義(P<0.01)。 FS 組患兒驚厥髮作後第1天 EEG 異常率為79.8%,其中 SFS 組78.3%,CFS 組85.7%,差異無統計學意義(P>0.05);第14天 EEG 異常率為24.0%,SFS 組僅16.3%,CFS 組則54.8%,2組比較差異具有統計學意義(P<0.01)。結論 FS 後及時測定血清 NSE 水平,併結閤 EEG 檢查對判斷腦損傷程度及預後具有重要價值。
목적:측정열성량궐(FS)환인혈청중신경원특이성희순화매(NSE)수평여뇌전도(EEG)변화,관찰NSE 여뇌손상적관계,이편지도림상치료화개선예후。방법선택 FS 조환인208례,기중단순성열성량궐(SFS)166례,복잡성열성량궐(CFS)42례,대조조위112명동기아원건강사체인동。 FS 조환인우량궐발작후24 h 내추취정맥혈채용전화학발광법검측혈청 NSE,대조조표본류취급처리방법상동。 FS 조환인분별우발병후제1천화제14천진행 EEG 검사。결과 FS 조환인혈청중 NSE 수평명현고우건강대조조(P<0.01);CFS 조여건강대조조화 SFS 조비교차이균구유통계학의의(P<0.01)。 FS 조환인량궐발작후제1천 EEG 이상솔위79.8%,기중 SFS 조78.3%,CFS 조85.7%,차이무통계학의의(P>0.05);제14천 EEG 이상솔위24.0%,SFS 조부16.3%,CFS 조칙54.8%,2조비교차이구유통계학의의(P<0.01)。결론 FS 후급시측정혈청 NSE 수평,병결합 EEG 검사대판단뇌손상정도급예후구유중요개치。
Objective To detect the levels of neuron-specific enolase(NSE) and change of electroencephalogram (EEG) in serum of febrile seizures (FS),and observe the relationship between NSE and brain injury to guide clinical treatment and prognosis. Methods From FS group 208 cases of children selected, including simple febrile seizures (SFS) 166 cases and complex febrile seizures (CFS) 42 patients. The control group over the same period 112 cases of child health checkedup in our hospital. NSE was detected by electrochemiluminescence from FS group of children in the seizure within 24 hours venous blood serum, specimens selected and processing method of control group was the same to the FS group. FS group were provided with EEG examination 1 and 14 days after the onset. Results FS group serum NSE level was significantly higher than the control group (P<0.01); CFS group and the control group and the SFS group differences were significant (P<0.01). FS after seizures in children with EEG abnormalities on day 1 was 79.8%, which SFS group 78.3%, CFS group 85.7%, the difference was not statistically significant (P>0.05); the first 14 days of EEG abnormality rate was 24.0%, SFS group only 16.3%, CFS group was 54.8%, the difference was significant (P<0.01). Conclusion After to detect FS to detect serum NSE level and combined with EEG examination to determine the degree and prognosis of brain damage is valuable.