光明中医
光明中醫
광명중의
GUANG MING JOURNAL TRADITIONAL CHINESE MEDICINE
2014年
8期
1615-1618
,共4页
Graves病%白细胞减少%益气养阴%IL-13%实验研究
Graves病%白細胞減少%益氣養陰%IL-13%實驗研究
Graves병%백세포감소%익기양음%IL-13%실험연구
Graves disease%Leukopenia%Yiqiyangyin%IL-13%Experimental study
目的:观察Graves病( GD)小鼠外周血白细胞计数和小鼠细胞因子IL-13表达及益气养阴方对其的影响。方法基因枪造模建立GD小鼠模型,应用中药益气养阴方治疗后,观察小鼠外周血白细胞计数和小鼠细胞因子IL-13表达的变化。结果治疗30天后,在外周血白细胞计数方面,中药益气养阴方高剂量组明显高于中药益气养阴方低剂量组、中剂量组( P <0.01);在降低甲状腺激素水平方面,中药益气养阴方高、中剂量组明显优于中药益气养阴方低剂量组;在小鼠细胞因子IL-13表达方面,西药他巴唑组小鼠细胞因子IL-13表达显升高,与正常对照组和模型组比较有显著差异性( P <0.01)。中药治疗组的IL-13mRNA表达与正对照组比较没有显著性差异,P>0.05。经中药益气养阴方治疗,小鼠IL-13mRNA的表达下调,即中药高剂量组表达最低,依次增高。结论益气养阴方对Graves病合并白细胞减少有较好的治疗作用,其机理可能在于其能较好地调节Graves病小鼠细胞因子IL-13水平,有促进免疫细胞成熟、活化、增殖和免疫调节的作用。
目的:觀察Graves病( GD)小鼠外週血白細胞計數和小鼠細胞因子IL-13錶達及益氣養陰方對其的影響。方法基因鎗造模建立GD小鼠模型,應用中藥益氣養陰方治療後,觀察小鼠外週血白細胞計數和小鼠細胞因子IL-13錶達的變化。結果治療30天後,在外週血白細胞計數方麵,中藥益氣養陰方高劑量組明顯高于中藥益氣養陰方低劑量組、中劑量組( P <0.01);在降低甲狀腺激素水平方麵,中藥益氣養陰方高、中劑量組明顯優于中藥益氣養陰方低劑量組;在小鼠細胞因子IL-13錶達方麵,西藥他巴唑組小鼠細胞因子IL-13錶達顯升高,與正常對照組和模型組比較有顯著差異性( P <0.01)。中藥治療組的IL-13mRNA錶達與正對照組比較沒有顯著性差異,P>0.05。經中藥益氣養陰方治療,小鼠IL-13mRNA的錶達下調,即中藥高劑量組錶達最低,依次增高。結論益氣養陰方對Graves病閤併白細胞減少有較好的治療作用,其機理可能在于其能較好地調節Graves病小鼠細胞因子IL-13水平,有促進免疫細胞成熟、活化、增殖和免疫調節的作用。
목적:관찰Graves병( GD)소서외주혈백세포계수화소서세포인자IL-13표체급익기양음방대기적영향。방법기인창조모건립GD소서모형,응용중약익기양음방치료후,관찰소서외주혈백세포계수화소서세포인자IL-13표체적변화。결과치료30천후,재외주혈백세포계수방면,중약익기양음방고제량조명현고우중약익기양음방저제량조、중제량조( P <0.01);재강저갑상선격소수평방면,중약익기양음방고、중제량조명현우우중약익기양음방저제량조;재소서세포인자IL-13표체방면,서약타파서조소서세포인자IL-13표체현승고,여정상대조조화모형조비교유현저차이성( P <0.01)。중약치료조적IL-13mRNA표체여정대조조비교몰유현저성차이,P>0.05。경중약익기양음방치료,소서IL-13mRNA적표체하조,즉중약고제량조표체최저,의차증고。결론익기양음방대Graves병합병백세포감소유교호적치료작용,기궤리가능재우기능교호지조절Graves병소서세포인자IL-13수평,유촉진면역세포성숙、활화、증식화면역조절적작용。
Objective To observe the effect of Yiqiyangyin decoction on the peripheral white blood cell count and IL -13 expression of GD Mice To discuss the mechanism of yiqiyangyin decoction to merger leukopenia .Methods To establish the model of GD mice by Gene gun . After the therapy of Yiqiyangyin decoction , we observed the peripheral white blood cell count and IL-13 expression alteration of GD Mice . Results After the treatment in 30 days, the peripheral white blood cell count in high-dose group of Yiqiyangyin decoction was significantly higher than low-dose group and middle-dose group ( P <0.01 ) .High-dose group and middle-dose group of Yiqiyangyin decoction was significantly superior to low-dose group in reducing thyroid hormones ,.The tapazole group decreased obviously , which was significant difference with normal group in IL-13 expression(P<0.01).There was no significant difference in IL-13mRNA expression between chinese medicine treatment group and normal group (P >0.05).After the treatment of Yiqiyangyin decoction , the IL-13mRNA expression down regulated,which mean High-dose group express the lowest , with gradually increasing .Conclusions Yiqiyangyin decoction has a better therapeutic effect to Graves disease combining with leukopenia .Its mechanism may be related with better regulating IL-13 expression . Yiqiyangyin decoction can promote the maturation , activation, proliferation, and immunodulatory of immune cell .