CAJ | 학술논문

目的：观察右归胶囊对腺嘌呤致肾阳虚不育模型大鼠生殖功能的影响。方法以腺嘌呤灌胃SD大鼠，诱发肾阳虚不育模型，观察右归胶囊给药后实验动物睾丸、附睾、前列腺＋精囊腺重量及睾丸曲细精管形态、曲细精管内各级生精细胞的数目和间质细胞的数目，各项指标皆与大鼠生殖功能有密切的关系。结果右归组大鼠左侧睾丸、右侧睾丸，左侧附睾、右侧附睾，前列腺＋精囊重量均低于正常组大鼠但高于模型组大鼠，差异有统计学意义。电镜下观察右归组大鼠睾丸病理切片，发现曲细精管萎缩较模型组明显减轻，各级生精细胞及间质细胞数量较模型组明显增多。结论右归胶囊可提高腺嘌呤致肾阳虚不育模型大鼠生殖器官的重量，减轻腺嘌呤对睾丸曲细精管及各级生精细胞的损伤作用，对肾阳虚不育模型大鼠生殖功能具有保护作用。
목적：관찰우귀효낭대선표령치신양허불육모형대서생식공능적영향。방법이선표령관위SD대서，유발신양허불육모형，관찰우귀효낭급약후실험동물고환、부고、전렬선＋정낭선중량급고환곡세정관형태、곡세정관내각급생정세포적수목화간질세포적수목，각항지표개여대서생식공능유밀절적관계。결과우귀조대서좌측고환、우측고환，좌측부고、우측부고，전렬선＋정낭중량균저우정상조대서단고우모형조대서，차이유통계학의의。전경하관찰우귀조대서고환병리절편，발현곡세정관위축교모형조명현감경，각급생정세포급간질세포수량교모형조명현증다。결론우귀효낭가제고선표령치신양허불육모형대서생식기관적중량，감경선표령대고환곡세정관급각급생정세포적손상작용，대신양허불육모형대서생식공능구유보호작용。
Objective To discuss the influence of Yougui capsule on Kidney-Yang deficiency in-fertility rats'reproductive function .Methods The Kidney-Yang deficiency infertility model was estab-lished by feeding adenine .And the influence of Yougui capsule on the rats'reproductive function was ob-served through the weight of reproductive organs and testis Microstructure .Results In the Yougui capsulegroup, the weight of reproductive organs were higher than the the model group ,but lower than the normalgroup.It could also improve the morphological changes of the tissue .In the Yougui capsule group, spermatogeniccells and mesenchymal cells are more than the model group .Its convoluted tubule morphology isalso better than the the model group.Conclusion Yougui capsule can improve the model group rats'weightof testis,epididymis,prostate,seminal vesicles.In addition , Yougui capsule can cut down the damage of adenine on spermatogenic cells and mesenchymal .So,we think that it can improve the model group rats'reproductivefunction.