CAJ | 학술논문

目的：比较口服吗啡片与静脉注射吗啡在重度癌痛治疗中的疗效及安全性。方法35例重度癌痛患者随机分为口服组（口服盐酸吗啡片）16例和静脉组（静脉推注吗啡）19例。结果口服组滴定疼痛至 CR /PR 的平均时间明显长于静脉组。2组不良反应发生率无显著差异。结论口服及静脉应用吗啡滴定治疗重度癌痛患者疗效显著，安全性高，静脉给药较口服起效更快，缓解疼痛更迅速，值得推广。
목적：비교구복마배편여정맥주사마배재중도암통치료중적료효급안전성。방법35례중도암통환자수궤분위구복조（구복염산마배편）16례화정맥조（정맥추주마배）19례。결과구복조적정동통지 CR /PR 적평균시간명현장우정맥조。2조불량반응발생솔무현저차이。결론구복급정맥응용마배적정치료중도암통환자료효현저，안전성고，정맥급약교구복기효경쾌，완해동통경신속，치득추엄。
Objective To compare the efficacy and safety of intravenous injection and oral taken of morphine in the treatment of severe cancer pain.Methods 35 patients with severe cancer pain were randomly divided into oral group (n =16)and IV group (n =19).Results The time from start of treatment to achievement of CR /PR in the oral group was significantly longer than that in the IV group,and there was no significant difference of incidence rate of complications be-tween two groups.Conclusion Both oral taken and intravenous injection of morphine can effec-tively alleviate severe cancer pain,and compared with oral take,the intravenous injection of mor-phine is even more effective,so it is worthy of popularization.