实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
13期
102-105
,共4页
糖尿病%功能性便秘%消化内科%双歧杆菌%乳果糖
糖尿病%功能性便祕%消化內科%雙歧桿菌%乳果糖
당뇨병%공능성편비%소화내과%쌍기간균%유과당
diabetes mellitus%functional constipation%mosapride%bifidobacterium%lactu-lose
目的：观察分析128例老年2型糖尿病功能性便秘患者消化内科治疗方法及临床疗效。方法选取128例老年2型糖尿病功能性便秘患者为研究对象，采用数字法随机将患者分为两组，其中观察组68例给予莫沙必利、乳果糖联合双歧杆菌治疗，对照组60例给予单纯莫沙必利治疗，观察比较两组患者临床疗效、症状改善、4～12周后复发率及不良反应情况。结果观察组总有效率为91．2％，高于对照组70．0％，治疗后观察组排便频率、排便困难程度、腹胀腹痛、排便不尽三项症状改善均优于对照组，观察组患者8～12周复发率为10．3％、16．2％，低于对照组23．3％、43．3％，在腹胀、腹泻、腹痛、腹部不适及总不良反应发生率均低于对照组（P ＜0．05）。结论消化内科采用莫沙必利、乳果糖联合双歧杆菌三联疗法治疗老年2型糖尿病功能性便秘临床疗效显著，能够有效的改善患者排便困难等临床症状，减少停药后复发率，不良反应较少，值得临床推广应用。
目的：觀察分析128例老年2型糖尿病功能性便祕患者消化內科治療方法及臨床療效。方法選取128例老年2型糖尿病功能性便祕患者為研究對象，採用數字法隨機將患者分為兩組，其中觀察組68例給予莫沙必利、乳果糖聯閤雙歧桿菌治療，對照組60例給予單純莫沙必利治療，觀察比較兩組患者臨床療效、癥狀改善、4～12週後複髮率及不良反應情況。結果觀察組總有效率為91．2％，高于對照組70．0％，治療後觀察組排便頻率、排便睏難程度、腹脹腹痛、排便不儘三項癥狀改善均優于對照組，觀察組患者8～12週複髮率為10．3％、16．2％，低于對照組23．3％、43．3％，在腹脹、腹瀉、腹痛、腹部不適及總不良反應髮生率均低于對照組（P ＜0．05）。結論消化內科採用莫沙必利、乳果糖聯閤雙歧桿菌三聯療法治療老年2型糖尿病功能性便祕臨床療效顯著，能夠有效的改善患者排便睏難等臨床癥狀，減少停藥後複髮率，不良反應較少，值得臨床推廣應用。
목적：관찰분석128례노년2형당뇨병공능성편비환자소화내과치료방법급림상료효。방법선취128례노년2형당뇨병공능성편비환자위연구대상，채용수자법수궤장환자분위량조，기중관찰조68례급여막사필리、유과당연합쌍기간균치료，대조조60례급여단순막사필리치료，관찰비교량조환자림상료효、증상개선、4～12주후복발솔급불량반응정황。결과관찰조총유효솔위91．2％，고우대조조70．0％，치료후관찰조배편빈솔、배편곤난정도、복창복통、배편불진삼항증상개선균우우대조조，관찰조환자8～12주복발솔위10．3％、16．2％，저우대조조23．3％、43．3％，재복창、복사、복통、복부불괄급총불량반응발생솔균저우대조조（P ＜0．05）。결론소화내과채용막사필리、유과당연합쌍기간균삼련요법치료노년2형당뇨병공능성편비림상료효현저，능구유효적개선환자배편곤난등림상증상，감소정약후복발솔，불량반응교소，치득림상추엄응용。
Objective To explore the effect of mosapride,lactulose and bifidobacterium on treatment of 128 elderly type 2 diabetic patients with functional constipation.Methods 128 elderly type 2 diabetic patients with functional constipation were randomly divided into observation group (n =68,treated with mosapride,lactulose and bifidobacterium)and the control group (n =60, treated with mosapride).Clinical curative effect after 4~12 weeks,recurrence rate and incidence rate of adverse reactions were compared between two groups.Results In the observation group, the total effective rate was 91.2%,which was higher than 70% in the control group.Defecation frequency,difficulty degree of defecation,abdominal distention,endless defecate in the observation group were better than the control group.The recurrence rate in the observation group was signifi-cantly lower than the control group.Incidence rate of adverse reactions such as abdominal disten-sion,diarrhea,abdominal discomfort in the observation group was significantly lower than the con-trol group (P <0.05).Conclusion Application of mosapride,lactulose and bifidobacterium triple therapy in treatment of elderly diabetic patients with functional constipation can effectively improve the clinical symptoms,reduce the relapse rate and avoid incidence of adverse reactions,so it is wor-thy of clinical application.
