实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
13期
94-96
,共3页
充血性心力衰竭%米力农%硝酸异山梨酯%心功能%疗效%安全性
充血性心力衰竭%米力農%硝痠異山梨酯%心功能%療效%安全性
충혈성심력쇠갈%미력농%초산이산리지%심공능%료효%안전성
congestive heart failure%milinong%nitrate yamanashi ester%cardiac function%curative effect%security
目的:探讨米力农与硝酸异山梨酯联合治疗充血性心力衰竭(CHF)对患者心功能的影响及安全性。方法分析本院自2012年1月-2014年1月收治的112例充血性心力衰竭患者,按照随机数字表法分为治疗组58组和对照组54例,两组均给予常规药物治疗,对照组在此基础上加用硝酸异山梨酯片,治疗组在对照组基础上加用米力农。观察两组临床总有效率、BNP 及超声心电图指标变化及安全性。结果①对照组与治疗组临床总有效率分别为75.9%(41/54),93.1%(54/58),两组比较(χ2=6.428,P <0.05);②两组治疗后与治疗前比较,BNP 水平、CI、CO、LVEF 各项指标比较(P <0.05),治疗后两组比较,BNP 水平、CI、CO、LVEF 各项指标均有显著改善(P <0.05);③治疗组与对照组不良反应发生率为6.9%(4/58)与5.6%(3/54),两组比较(χ2=0.086,P >0.05)。结论米力农与硝酸异山梨酯联合治疗充血性心力衰竭,可以提高临床有效率,改善 BNP 及心电解质水平,且安全性好,值得临床推广应用。
目的:探討米力農與硝痠異山梨酯聯閤治療充血性心力衰竭(CHF)對患者心功能的影響及安全性。方法分析本院自2012年1月-2014年1月收治的112例充血性心力衰竭患者,按照隨機數字錶法分為治療組58組和對照組54例,兩組均給予常規藥物治療,對照組在此基礎上加用硝痠異山梨酯片,治療組在對照組基礎上加用米力農。觀察兩組臨床總有效率、BNP 及超聲心電圖指標變化及安全性。結果①對照組與治療組臨床總有效率分彆為75.9%(41/54),93.1%(54/58),兩組比較(χ2=6.428,P <0.05);②兩組治療後與治療前比較,BNP 水平、CI、CO、LVEF 各項指標比較(P <0.05),治療後兩組比較,BNP 水平、CI、CO、LVEF 各項指標均有顯著改善(P <0.05);③治療組與對照組不良反應髮生率為6.9%(4/58)與5.6%(3/54),兩組比較(χ2=0.086,P >0.05)。結論米力農與硝痠異山梨酯聯閤治療充血性心力衰竭,可以提高臨床有效率,改善 BNP 及心電解質水平,且安全性好,值得臨床推廣應用。
목적:탐토미력농여초산이산리지연합치료충혈성심력쇠갈(CHF)대환자심공능적영향급안전성。방법분석본원자2012년1월-2014년1월수치적112례충혈성심력쇠갈환자,안조수궤수자표법분위치료조58조화대조조54례,량조균급여상규약물치료,대조조재차기출상가용초산이산리지편,치료조재대조조기출상가용미력농。관찰량조림상총유효솔、BNP 급초성심전도지표변화급안전성。결과①대조조여치료조림상총유효솔분별위75.9%(41/54),93.1%(54/58),량조비교(χ2=6.428,P <0.05);②량조치료후여치료전비교,BNP 수평、CI、CO、LVEF 각항지표비교(P <0.05),치료후량조비교,BNP 수평、CI、CO、LVEF 각항지표균유현저개선(P <0.05);③치료조여대조조불량반응발생솔위6.9%(4/58)여5.6%(3/54),량조비교(χ2=0.086,P >0.05)。결론미력농여초산이산리지연합치료충혈성심력쇠갈,가이제고림상유효솔,개선 BNP 급심전해질수평,차안전성호,치득림상추엄응용。
Objective To explore the influence and safety of milinong and nitrate yamanashi ester on cardiac function of patients with congestive heart failure (CHF).Methods 112 patients with CHF were randomly divided intotreatment group (n =58)and control group (n =54).All pa-tients were given routine drug treatment,the control group was treated with additional nitrate ya-manashi ester,while the treatment group was treated with additional nitrate yamanashi ester and milinong.Clinical total effective rate,the BNP and ultrasonic cardiogram index change and security werecomparedbetween twogroups .Results The total effective ratewas7 5 .9 % (4 1 /5 4 )and 93.1% (54 /58)in control group and treatment group respectively (χ2=6.428,P <0.05).The levels ofBNP ,CI ,CO ,LVEF after treatment in treatment in groups improved significantly (P <0.05),and the levels of BNP,CI,CO,LVEF after treatment in treatment group were significant-ly better than control group (P <0.05).The incidence rate of adverse reactions was 6.9% (4 /58) and 5.6% (3 /54)in treatment group and control group respectively (χ2 =0.086,P >0.086). Conclusion Application of milinong combined with nitrate yamanashi ester in treatment of CHF can improve the clinical effective rate,the BNP and heart electrolyte level.