CAJ | 학술논문

目的：观察脱氢表雄酮（DHEA）对卵巢储备功能下降（DOR）患者的影响。方法选取21例有≥1次体外受精-胚胎移植（IVF-ET）失败经历，口服75 mg /d DHEA 3个月后再次行 IVF-ET 治疗的 DOR 患者，比较口服 DHEA 前后 IVF-ET周期相关指标变化情况。结果 DHEA 降低了患者基础卵泡刺激素（FSH）和雌二醇（E2），增加了基础双侧窦卵泡数（AFC）；改善了控制性超促排卵（COH）周期的相关指标；提高了 IVF-ET 妊娠率，降低了流产率。结论 DHEA 改善了 DOR 患者卵巢反应性，有助于 IVF-ET 临床结局的提升。
목적：관찰탈경표웅동（DHEA）대란소저비공능하강（DOR）환자적영향。방법선취21례유≥1차체외수정-배태이식（IVF-ET）실패경력，구복75 mg /d DHEA 3개월후재차행 IVF-ET 치료적 DOR 환자，비교구복 DHEA 전후 IVF-ET주기상관지표변화정황。결과 DHEA 강저료환자기출란포자격소（FSH）화자이순（E2），증가료기출쌍측두란포수（AFC）；개선료공제성초촉배란（COH）주기적상관지표；제고료 IVF-ET 임신솔，강저료유산솔。결론 DHEA 개선료 DOR 환자란소반응성，유조우 IVF-ET 림상결국적제승。
Objective To observe the effect of dehidroepiandroszteron (DHEA)on dimin-ished ovarian reserve (DOR)patients with failed in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 21 patients with ≥1 time of failed IVF-ET were orally administered with 75 mg /d DHEA for 3 months,and IVF-ET was performed again.Relevant indexes in IVF-ET cy-cle before and after oral administration of DHEA were compared.Results DHEA reduced the basic follicle stimulating hormone (FSH)and estradiol (E2)levels,increase basic bilateral antral follicle count (AFC)account,improve relevant indexes in controlled ovarian hyperstimulation (COH)cy-cle,promote pregnant rate in IVF-ET and reduce abortion rate.Conclusion DHEA can effectively improve ovarian response and clinical outcome of IVF-ET for DOR patients.