CAJ | 학술논문

目的：探讨白细胞介素-6（IL-6）和白细胞介素8（IL-8）对监测胎膜早破（PROM）孕妇绒毛膜羊膜炎的临床价值。方法选择在本院分娩的 PROM 孕妇45例作为研究组，同时选择同期在本院分娩的正常孕妇30例作为对照组，采用酶联免疫吸附法（ELISA）测定2组血清 IL-6及 IL-8水平，并于产后取胎膜组织做病理检查。结果研究组血清 IL-6及 IL-8水平显著高于对照组，差异有统计学意义。研究组产后胎膜组织病理检查诊断为绒毛膜羊膜炎28例（62．2％）为感染组，非绒毛膜羊膜炎17例（37．8％）为非感染组，感染组血清 IL-6及 IL-8水平显著高于非感染组，差异均有统计学意义。结论孕妇血清中IL-6及 IL-8的联合检测可作为监测 PROM 合并绒毛膜羊膜炎的重要指标。
목적：탐토백세포개소-6（IL-6）화백세포개소8（IL-8）대감측태막조파（PROM）잉부융모막양막염적림상개치。방법선택재본원분면적 PROM 잉부45례작위연구조，동시선택동기재본원분면적정상잉부30례작위대조조，채용매련면역흡부법（ELISA）측정2조혈청 IL-6급 IL-8수평，병우산후취태막조직주병리검사。결과연구조혈청 IL-6급 IL-8수평현저고우대조조，차이유통계학의의。연구조산후태막조직병리검사진단위융모막양막염28례（62．2％）위감염조，비융모막양막염17례（37．8％）위비감염조，감염조혈청 IL-6급 IL-8수평현저고우비감염조，차이균유통계학의의。결론잉부혈청중IL-6급 IL-8적연합검측가작위감측 PROM 합병융모막양막염적중요지표。
Objective To explore the clinical value of interleukin-6 (IL-6)and interleukin-8 (IL-8)in monitoring chorioamnionitis of pregnant women with premature rupture of membrane (PROM).Methods Forty-five pregnant women with PROM delivered in our hospital were select-ed as research group,and 30 normal pregnant women in our hospital were collected as control group at the same term.The levels of serum IL-6 and IL-8 in both groups were detected with enzyme-linked immunosorbent assay (ELISA),and the fetal membrane tissues were taken to conduct patho-logical examination after delivery.Results The levels of serum IL-6 and IL-8 in research group were significantly higher than in control group,with statistical significance.According to the patho-logical examination on fetal membrane tissues,28 patients (62.2%)were diagnosed as chorioam-nionitis (infection group),and 17 ones (37.8%)were not (non-infection group).The levels of serum IL-6 and IL-8 in infection group were significantly higher than in non-infection group,in which significant differences were presented.Conclusion Joint detection of IL-6 and IL-8 in serum of pregnant women can be used as the important index for monitoring PROM combined with chorioamnionitis.