实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
13期
29-32
,共4页
复方谷氨酰胺%益生菌%溃疡性结肠炎%肠道屏障%细胞因子
複方穀氨酰胺%益生菌%潰瘍性結腸炎%腸道屏障%細胞因子
복방곡안선알%익생균%궤양성결장염%장도병장%세포인자
compound glutamine%probiotics%ulcerative colitis%intestinal barrier func-tion%cytokine
目的：探讨复方谷氨酰胺与枯草杆菌二联活菌联合治疗活动期溃疡性结肠炎对患者肠道功能以及细胞因子的影响。方法66例溃疡性结肠炎患者随机分为观察组（n ＝33）与对照组（n ＝33），对照组给予美沙拉嗪治疗，观察组在对照组基础上加用枯草杆菌二联活菌与复方谷氨酰胺治疗，对比2组患者临床效果、肠道屏障功能（采用糖分子探针乳果糖/甘露醇比值，即 L /M 比值）以及细胞因子（IL-8及 TNF-α）的变化。结果观察组总有效率及结肠镜检查缓解率均为100．0％，显著高于对照组的81．8％及84．8％（P ＜0．05）；2组患者 IL-8及 TNF-α均较前显著减低（P ＜0．01），且治疗后观察组均显著低于对照组（P ＜0．01）；观察组患者 L /M 治疗后显著减低（P ＜0．01），对照组未见明显变化（P ＞0．05），治疗后观察组显著低于对照组（P ＜0．01）。结论传统治疗基础上联合益生菌与复方谷氨酰胺在 UC 治疗中具有确切的疗效，同时对于肠道屏障功能的恢复及细胞因子的降低也具有重要意义。
目的：探討複方穀氨酰胺與枯草桿菌二聯活菌聯閤治療活動期潰瘍性結腸炎對患者腸道功能以及細胞因子的影響。方法66例潰瘍性結腸炎患者隨機分為觀察組（n ＝33）與對照組（n ＝33），對照組給予美沙拉嗪治療，觀察組在對照組基礎上加用枯草桿菌二聯活菌與複方穀氨酰胺治療，對比2組患者臨床效果、腸道屏障功能（採用糖分子探針乳果糖/甘露醇比值，即 L /M 比值）以及細胞因子（IL-8及 TNF-α）的變化。結果觀察組總有效率及結腸鏡檢查緩解率均為100．0％，顯著高于對照組的81．8％及84．8％（P ＜0．05）；2組患者 IL-8及 TNF-α均較前顯著減低（P ＜0．01），且治療後觀察組均顯著低于對照組（P ＜0．01）；觀察組患者 L /M 治療後顯著減低（P ＜0．01），對照組未見明顯變化（P ＞0．05），治療後觀察組顯著低于對照組（P ＜0．01）。結論傳統治療基礎上聯閤益生菌與複方穀氨酰胺在 UC 治療中具有確切的療效，同時對于腸道屏障功能的恢複及細胞因子的降低也具有重要意義。
목적：탐토복방곡안선알여고초간균이련활균연합치료활동기궤양성결장염대환자장도공능이급세포인자적영향。방법66례궤양성결장염환자수궤분위관찰조（n ＝33）여대조조（n ＝33），대조조급여미사랍진치료，관찰조재대조조기출상가용고초간균이련활균여복방곡안선알치료，대비2조환자림상효과、장도병장공능（채용당분자탐침유과당/감로순비치，즉 L /M 비치）이급세포인자（IL-8급 TNF-α）적변화。결과관찰조총유효솔급결장경검사완해솔균위100．0％，현저고우대조조적81．8％급84．8％（P ＜0．05）；2조환자 IL-8급 TNF-α균교전현저감저（P ＜0．01），차치료후관찰조균현저저우대조조（P ＜0．01）；관찰조환자 L /M 치료후현저감저（P ＜0．01），대조조미견명현변화（P ＞0．05），치료후관찰조현저저우대조조（P ＜0．01）。결론전통치료기출상연합익생균여복방곡안선알재 UC 치료중구유학절적료효，동시대우장도병장공능적회복급세포인자적강저야구유중요의의。
Objective To explore the influence of compound glutamine combined with pro-biotics on intestinal barrier function and cytokine in patients with ulcerative colitis (UC).Methods 66 patients with UC were randomly divided into the control group (n =33)and the observation group (n =33).The control group was treated with mesalazine,while the observation group was treated with compound and probiotics on the basis of control group.Clinical efficacy,intestinal bar-rier function and cytokine were compared between the two groups.Results The total effective rate and colonoscopy remission rate of the observation group were 100.0%,which were significantly higher than 81.8% and 84.8% of the control group (P <0.05).After the treatment,IL-8 and TNF-αwere significantly lower than those before treatment (P <0.01),and the indexes of the observation group were significantly lower than the control group (P <0.01).L /M in the observa-tion group was significantly lower than that before treatment and the control group (P <0.01),but there was no significant difference in the control group (P >0.05).Conclusion Compound glu-tamine combined with probiotics based on the traditional treatment shows significant effects in treat-ment of patients with UC,and it also has an important significance in the recovery of intestinal bar-rier function and reduction of cytokine.
