CAJ | 학술논문

目的：探索血浆纤溶系统是否有助于鉴别不稳定性心绞痛及稳定性心绞痛。方法回顾性分析2010年1月至2014年1月在我院接受治疗的冠心病（心绞痛）患者的临床资料。依据患者冠心病类型分为2组：观察组：不稳定性心绞痛；对照组：稳定性心绞痛。结果共纳入患者178例，观察组87（48．88％）例，对照组91（51．12％）例。观察组患者血浆 CRP 水平显著高于对照组（11．83±4．92 vs 7．03±3．05；t ＝7．861，P ＜0．001）；观察组血浆纤溶酶原激活物抑制物-1（PAI-1）水平显著高于对照组（43．86±10．97 vs37．97±7．89；t ＝4．126，P ＜0．001）。心绞痛患者血浆CRP与PAI-1呈现显著正相关（r ＝0．189，P ＝0．012）。PAI-1区分稳定性心绞痛及不稳定性心绞痛的诊断分界点为109．5 mg/L，曲线下面积为0．947，敏感性为90．91％，特异性为91．11％。结论 PAI-1在不稳定性心绞痛患者外周血中显著升高，其区分稳定性心绞痛与不稳定性心绞痛的价值优于 CRP。
목적：탐색혈장섬용계통시부유조우감별불은정성심교통급은정성심교통。방법회고성분석2010년1월지2014년1월재아원접수치료적관심병（심교통）환자적림상자료。의거환자관심병류형분위2조：관찰조：불은정성심교통；대조조：은정성심교통。결과공납입환자178례，관찰조87（48．88％）례，대조조91（51．12％）례。관찰조환자혈장 CRP 수평현저고우대조조（11．83±4．92 vs 7．03±3．05；t ＝7．861，P ＜0．001）；관찰조혈장섬용매원격활물억제물-1（PAI-1）수평현저고우대조조（43．86±10．97 vs37．97±7．89；t ＝4．126，P ＜0．001）。심교통환자혈장CRP여PAI-1정현현저정상관（r ＝0．189，P ＝0．012）。PAI-1구분은정성심교통급불은정성심교통적진단분계점위109．5 mg/L，곡선하면적위0．947，민감성위90．91％，특이성위91．11％。결론 PAI-1재불은정성심교통환자외주혈중현저승고，기구분은정성심교통여불은정성심교통적개치우우 CRP。
Objective To explore the value of plasminogen activator inhibitor-1 (PAI-1)in differential diagnosis of stable angina and unstable angina.Methods Clinical materials of 178 pa-tients with angina were analyzed retrospectively,and they were divided into Observation group (unsta-ble angina,n =87)and control group (stable angina,n =91)according to type of angina.Results Levels of CRP and PAI-1 in the observation group were significantly lower than those in the control group (P <0.001).There was a significant positive correlation between CRP and PAI-1 (r =0.189, P =0.012)in patients with angina.ROC analysis showed PAI-1 was able to differentiate unstable an-gina and stable angina with a cut-off value of 109.5 mg/L,a AUC of 0.947,a sensibility of 90.91%and a specificity of 91.11%.Conclusion Unstable angina patients have a higher level of PAI-1 than stable angina patients.PAI-1 can be used to differentiate unstable angina and stable angina.