实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
13期
1-3
,共3页
韩志刚%俞婷婷%申红丽%阿力木江·赛提瓦尔地
韓誌剛%俞婷婷%申紅麗%阿力木江·賽提瓦爾地
한지강%유정정%신홍려%아력목강·새제와이지
Napsin-A%非小细胞肺癌%表皮生长因子受体%腺癌%鳞癌
Napsin-A%非小細胞肺癌%錶皮生長因子受體%腺癌%鱗癌
Napsin-A%비소세포폐암%표피생장인자수체%선암%린암
Napsin-A%non-small cell lung cancer%epidermal growth factor receptor%ade-nosquamous carcinoma%squamous carcinoma
目的：探讨非小细胞肺癌（NSCLC）组织中 Napsin-A 表达与表皮生长因子受体（EGFR）基因的关系。方法采用免疫组织化学法检测89例肺腺鳞癌组织中 Napsin-A 的表达情况，并用 ARMS 试剂盒检测上述组织中 EGFR 基因的表达情况，分析 Napsin-A 的表达与 EGFR 基因的关系。结果在 NSCLC 组织中，腺癌和鳞癌的 Napsin-A 阳性率分别为96．2％和5．6％，两者比较差异有统计学意义。肺腺癌组织中，EGFR 基因突变率为54．7％，而 Napsin-A 表达阳性者的突变率高达100．0％；肺鳞癌组织中，EGFR 基因突变率为5．6％，而 Napsin-A 表达阳性者的突变率为50．0％，两者比较，差异有统计学意义。结论Napsin-A 在肺腺癌组织中高表达，且在腺鳞癌中表达阳性者 EGFR 基因突变率较高，Napsin-A 表达阳性者可建议行 EGFR 基因检测。
目的：探討非小細胞肺癌（NSCLC）組織中 Napsin-A 錶達與錶皮生長因子受體（EGFR）基因的關繫。方法採用免疫組織化學法檢測89例肺腺鱗癌組織中 Napsin-A 的錶達情況，併用 ARMS 試劑盒檢測上述組織中 EGFR 基因的錶達情況，分析 Napsin-A 的錶達與 EGFR 基因的關繫。結果在 NSCLC 組織中，腺癌和鱗癌的 Napsin-A 暘性率分彆為96．2％和5．6％，兩者比較差異有統計學意義。肺腺癌組織中，EGFR 基因突變率為54．7％，而 Napsin-A 錶達暘性者的突變率高達100．0％；肺鱗癌組織中，EGFR 基因突變率為5．6％，而 Napsin-A 錶達暘性者的突變率為50．0％，兩者比較，差異有統計學意義。結論Napsin-A 在肺腺癌組織中高錶達，且在腺鱗癌中錶達暘性者 EGFR 基因突變率較高，Napsin-A 錶達暘性者可建議行 EGFR 基因檢測。
목적：탐토비소세포폐암（NSCLC）조직중 Napsin-A 표체여표피생장인자수체（EGFR）기인적관계。방법채용면역조직화학법검측89례폐선린암조직중 Napsin-A 적표체정황，병용 ARMS 시제합검측상술조직중 EGFR 기인적표체정황，분석 Napsin-A 적표체여 EGFR 기인적관계。결과재 NSCLC 조직중，선암화린암적 Napsin-A 양성솔분별위96．2％화5．6％，량자비교차이유통계학의의。폐선암조직중，EGFR 기인돌변솔위54．7％，이 Napsin-A 표체양성자적돌변솔고체100．0％；폐린암조직중，EGFR 기인돌변솔위5．6％，이 Napsin-A 표체양성자적돌변솔위50．0％，량자비교，차이유통계학의의。결론Napsin-A 재폐선암조직중고표체，차재선린암중표체양성자 EGFR 기인돌변솔교고，Napsin-A 표체양성자가건의행 EGFR 기인검측。
Objective To explore the relationship between Napsin-A expression and epider-mal growth factor receptor (EGFR)genes in non-small cell lung cancer (NSCLC)tissue.Methods Napsin-A expression in 89 adenosquamous carcinoma tissues of the lung was detected by immunohisto-chemistry,and the expression of EGFR genes in the tissues above was also detected by ARMS kit.The relationship between Napsin-A expression and EGFR was analyzed.Results The Napsin-A positive rates of adenocarcinoma and squamous carcinoma in NSCLC tissue were 96.2% and 5.6%,respec-tively,and there was statistical significance between them.The mutation rate of EGFR gene in lung adenocarcinoma tissue was 54.7%,while that of the patients with positive Napsin-A expression came up to 100.0%.The mutation rate of EGFR gene in lung squamous tissue was 5.6%,while that of the patients with positive Napsin-A expression came up to 50.0%,in which significant difference was presented by comparison to them.Conclusion Napsin-A is highly expressed in lung adenocarcinoma tissue,and the EGFR mutation rate of patients with positive expression in adenosquamous carcinoma is also high.Hence,for the patients with positive Napsin-A expression,it should be recommended to de-tect EGFR genes.
