CAJ | 학술논문

目的：探讨脂联素与慢性乙型肝炎病毒感染肝纤维化的相关性。方法60例慢性乙型肝炎患者根据肝纤维化程度分为轻度肝纤维化组（n ＝28），重度肝纤维化组（n ＝17）和肝硬化组（n ＝15），另选取20例健康体检人员设为对照组。检测各组血清脂联素水平。结果各组血清脂联素水平比较，差异均有统计学意义（P ＜0．05），且血清脂联素水平与肝纤维化分级存在显著正相关（r ＝0．967，P ＜0．05）；肝硬化组肝组织脂联素表达率为93．33％，明显高于轻度（14．29％）及重度纤维化组（41．18％），差异均有统计学意义（P ＜0．05）。结论脂联素与慢性乙型肝炎肝纤维化的进程密切相关。
목적：탐토지련소여만성을형간염병독감염간섬유화적상관성。방법60례만성을형간염환자근거간섬유화정도분위경도간섬유화조（n ＝28），중도간섬유화조（n ＝17）화간경화조（n ＝15），령선취20례건강체검인원설위대조조。검측각조혈청지련소수평。결과각조혈청지련소수평비교，차이균유통계학의의（P ＜0．05），차혈청지련소수평여간섬유화분급존재현저정상관（r ＝0．967，P ＜0．05）；간경화조간조직지련소표체솔위93．33％，명현고우경도（14．29％）급중도섬유화조（41．18％），차이균유통계학의의（P ＜0．05）。결론지련소여만성을형간염간섬유화적진정밀절상관。
Objective To explore the correlation between adiponectin and liver fibrosis in patients with chronic hepatitis B virus infection.Methods 60 patients with chronic hepatitis B were divided into mild liver fibrosis group (n =28),severe liver fibrosis group (n =17)and cirrho-sis group (n =15),and 20 healthy volunteers were designed as the control group.The serum adiponectin level was detected in all the groups.Results There were significant differences of serum adiponectin levels among the four groups (P <0.05),and there was a positive correlation be-tween serum adiponectin level and liver fibrosis grade (r =0.967,P <0.05).The expression rate of liver tissue adiponectin in cirrhosis group was 93.33%,which was significantly higher than the mild group (14.29%)and severe fibrosis group (41.18%)(P <0.05).Conclusion Adiponectin is closely related to the liver fibrosis in patients with chronic hepatitis B virus infection.