CAJ | 학술논문

目的：探讨血小板参数的检测在成人重度原发免疫性血小板减少症（ITP）诊断和疗效判断的临床意义。方法选取本院收治的34例原发重度 ITP 患者为观察组，另选取30例本院同期健康体检者为对照组。记录2组治疗前和观察组治疗3、7 d 后血小板参数值。结果治疗前，观察组血小板计数（PLT）、血小板比积（PCT）显著低于对照组（P ＜0．05），平均血小板体积（MPV）明显高于对照组（P ＜0．05），而血小板分布宽度（PDW）无明显差异（P ＞0．05）。与治疗前比较，观察组治疗3 d 后 PLT、PCT、MPV 均明显增加（P ＜0．05），治疗7 d 后 PLT、PCT、PDW 均有显著增加（P ＜0．05）。结论血小板参数对判断重度原发 ITP 患者病情进展和疗效均有重要临床意义。
목적：탐토혈소판삼수적검측재성인중도원발면역성혈소판감소증（ITP）진단화료효판단적림상의의。방법선취본원수치적34례원발중도 ITP 환자위관찰조，령선취30례본원동기건강체검자위대조조。기록2조치료전화관찰조치료3、7 d 후혈소판삼수치。결과치료전，관찰조혈소판계수（PLT）、혈소판비적（PCT）현저저우대조조（P ＜0．05），평균혈소판체적（MPV）명현고우대조조（P ＜0．05），이혈소판분포관도（PDW）무명현차이（P ＞0．05）。여치료전비교，관찰조치료3 d 후 PLT、PCT、MPV 균명현증가（P ＜0．05），치료7 d 후 PLT、PCT、PDW 균유현저증가（P ＜0．05）。결론혈소판삼수대판단중도원발 ITP 환자병정진전화료효균유중요림상의의。
Objective To explore the clinical significance of detecting platelet parameters in the diagnosis and efficacy-evaluation of adult severe primary immune thrombocytopenia (ITP). Methods Thirty-four adult patients with primary ITP admitted in our hospital served as observa-tion group while another 30 healthy people undergoing physical examination as control group. Platelet parameters on both groups before treatment and in observation group 3and 7 days after treatment were observed.Results Before treatment,observation group was evidently lower in platelet count (PLT)and plateletocrit (PCT)and obviously higher in mean platelet volume (MPV) than control group (P <0.05),but there was no significant difference in platelet distributive width (PDW)(P >0.05).Compared with treatment before,PLT,PCT,MPV increased more markedly 3 d after treatment while PLT,PCT,PDW increased significantly 7 days after treatment in obser-vation group (P <0.05).Conclusion Platelet parameters have important clinical significance in e-valuating the progression and efficacy of adult patients with severe primary ITP.