实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
15期
118-120
,共3页
糖皮质激素%雾化吸入%哮喘%急性发作
糖皮質激素%霧化吸入%哮喘%急性髮作
당피질격소%무화흡입%효천%급성발작
glucocorticoids%aerosol inhalation%asthma%acute attack
目的：探讨雾化吸入高剂量糖皮质激素对急性发作期儿童哮喘疗效的影响。方法将本院儿科收治的93例哮喘儿童随机分为治疗组48例和对照组45例，2组均接受吸氧等常规治疗，在此基础上，治疗组雾化吸入高剂量糖皮质激素联合异丙托溴胺；对照组口服糖皮质激素激素片，并常规吸入异丙托溴胺。治疗前及治疗后1 h，密切监测2组患儿心率（HR）、呼吸频率（RR）、第1秒用力呼气容积（FEV1）、最大呼气流速（PEF）、血氧饱和度（SpO2）等临床指标，比较2组临床疗效，并观察不良反应发生情况。结果治疗组总有效率为97．9％，显著高于对照组的82．2％（P ＜0．05）。与治疗前比较，2组治疗后1 h HR、RR 明显减慢，FEV1、PEF 显著改善，且 SpO2明显增加，其中治疗组 HR、RR、FEV1、PEF 及 SpO2改善程度显著优于对照组（P ＜0．05或P ＜0．01）。治疗组不良反应总发生率12．5％（6/48），对照组为17．8％（8/45），2组差异无统计学意义（P ＞0．05）。结论对于急性发作期的哮喘儿童，雾化吸入高剂量糖皮质激素联合异丙托溴胺能快速缓解症状，改善肺功能，增加SpO2，且不良反应较轻。
目的：探討霧化吸入高劑量糖皮質激素對急性髮作期兒童哮喘療效的影響。方法將本院兒科收治的93例哮喘兒童隨機分為治療組48例和對照組45例，2組均接受吸氧等常規治療，在此基礎上，治療組霧化吸入高劑量糖皮質激素聯閤異丙託溴胺；對照組口服糖皮質激素激素片，併常規吸入異丙託溴胺。治療前及治療後1 h，密切鑑測2組患兒心率（HR）、呼吸頻率（RR）、第1秒用力呼氣容積（FEV1）、最大呼氣流速（PEF）、血氧飽和度（SpO2）等臨床指標，比較2組臨床療效，併觀察不良反應髮生情況。結果治療組總有效率為97．9％，顯著高于對照組的82．2％（P ＜0．05）。與治療前比較，2組治療後1 h HR、RR 明顯減慢，FEV1、PEF 顯著改善，且 SpO2明顯增加，其中治療組 HR、RR、FEV1、PEF 及 SpO2改善程度顯著優于對照組（P ＜0．05或P ＜0．01）。治療組不良反應總髮生率12．5％（6/48），對照組為17．8％（8/45），2組差異無統計學意義（P ＞0．05）。結論對于急性髮作期的哮喘兒童，霧化吸入高劑量糖皮質激素聯閤異丙託溴胺能快速緩解癥狀，改善肺功能，增加SpO2，且不良反應較輕。
목적：탐토무화흡입고제량당피질격소대급성발작기인동효천료효적영향。방법장본원인과수치적93례효천인동수궤분위치료조48례화대조조45례，2조균접수흡양등상규치료，재차기출상，치료조무화흡입고제량당피질격소연합이병탁추알；대조조구복당피질격소격소편，병상규흡입이병탁추알。치료전급치료후1 h，밀절감측2조환인심솔（HR）、호흡빈솔（RR）、제1초용력호기용적（FEV1）、최대호기류속（PEF）、혈양포화도（SpO2）등림상지표，비교2조림상료효，병관찰불량반응발생정황。결과치료조총유효솔위97．9％，현저고우대조조적82．2％（P ＜0．05）。여치료전비교，2조치료후1 h HR、RR 명현감만，FEV1、PEF 현저개선，차 SpO2명현증가，기중치료조 HR、RR、FEV1、PEF 급 SpO2개선정도현저우우대조조（P ＜0．05혹P ＜0．01）。치료조불량반응총발생솔12．5％（6/48），대조조위17．8％（8/45），2조차이무통계학의의（P ＞0．05）。결론대우급성발작기적효천인동，무화흡입고제량당피질격소연합이병탁추알능쾌속완해증상，개선폐공능，증가SpO2，차불량반응교경。
Objective To investigate the effect of aerosol inhalation of high-dose glucocor-ticoids on children with asthma at acute attack stage.Methods Ninety-three asthmatic children re-ceived in our hospital were randomly divided into treatment group (48 cases)and control group (45 cases).Both groups were given routine treatment like oxygen uptake.Besides,the treatment group was treated with aerosol inhalation of high-dose glucocorticoids and ipratropium bromide,while the control group was given glucocorticoid tablets and routine inhalation of ipratropium bromide.Before and 1 h after treatment,the heart rate (HR),respiratory rate (RR),forced expiratory volume in 1 second (FEV1),peak expiratory flow (PEF)and SpO2 of children in both groups were strictly monitored,clinical efficacies were compared and adverse reactions were observed.Results The overall response rate of treatment group (9 7 .9 % )was significantly higher than control group (82.2%)(P <0.05),with statistical significant difference.Compared with treatment before,the HR and RR slowed down markedly,FEV1 and PEF were improved and SpO2 increased obviously in both groups 1 h after treatment,in which the improved degrees of all the above indexes in treatment group were superior to control group ,with statistical significant differences (P < 0 .0 5 ,or P <0.01).The total incidence rate of adverse reactions was 12.5% (6 /48)and the total incidence rate of control group was 17.8% (8 /45),and there were no significant differences between 2 groups (P>0.05).Conclusion For the asthmatic children at acute attack stage,aerosol inhalation of high-dose glucocorticoids and ipratropium bromide can rapidly alleviate symptoms,ameliorate the lung function and elevate SpO2,with milder adverse reactions.
