CAJ | 학술논문

目的：探讨妊娠期肝内胆汁淤积症（ICP）胆汁酸、肝酶指标对新生儿预后的影响。方法选取35例妊娠期肝内胆汁淤积症患者作为观察组，分析 ICP 孕妇总胆汁酸（TBA）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、新生儿出生的胎龄、羊水粪染情况以及胆汁酸与新生儿出生的胎龄、胎儿体质量、羊水粪染情况及新生儿窒息的关系，并选取同期分娩的60例正常孕妇作为对照组，将2组进行比较分析。结果观察组孕妇 TBA、ALT 以及 AST 均明显高于对照组，2组比较有显著性差异（P ＜0．05）；观察组新生儿胎龄、体质量明显低于对照组，2组比较有显著差异（P ＜0．05）；与对照组比较，观察组新生儿窒息率、羊水粪染率及胎儿宫内窘迫率明显较高，2组比较有显著差异（P ＜0．05）。结论妊娠期肝内胆汁淤积症孕妇中的胆汁酸、肝酶指标的升高，可能是引起胎儿缺氧、增加新生儿不良预后发生的主要原因，应予以积极防治。
목적：탐토임신기간내담즙어적증（ICP）담즙산、간매지표대신생인예후적영향。방법선취35례임신기간내담즙어적증환자작위관찰조，분석 ICP 잉부총담즙산（TBA）、병안산전안매（ALT）、천동안산전안매（AST）、신생인출생적태령、양수분염정황이급담즙산여신생인출생적태령、태인체질량、양수분염정황급신생인질식적관계，병선취동기분면적60례정상잉부작위대조조，장2조진행비교분석。결과관찰조잉부 TBA、ALT 이급 AST 균명현고우대조조，2조비교유현저성차이（P ＜0．05）；관찰조신생인태령、체질량명현저우대조조，2조비교유현저차이（P ＜0．05）；여대조조비교，관찰조신생인질식솔、양수분염솔급태인궁내군박솔명현교고，2조비교유현저차이（P ＜0．05）。결론임신기간내담즙어적증잉부중적담즙산、간매지표적승고，가능시인기태인결양、증가신생인불량예후발생적주요원인，응여이적겁방치。
Objective To investigate effect of bile acid and liver enzyme index on prognosis of neonates in intrahepatic cholestasis of pregnancy (ICP).Methods 35 pregnant patients with in-trahepatic cholestasis were as the observation group,and the relationship between ICP pregnant women,total bile acid (TBA),alanine aminotransferase (ALT),aspartate aminotransferase (AST),gestational age,newborn meconium-staining amniotic fluid and bile acid,the birth of ges-tational age,birth weight,meconium stained amniotic fluid and neonatal asphyxia were analyzed. 60 normal pregnant women during the same period were selected as control group,and the data of the two groups were comparative analyzed.Results In the observation group,TBA,ALT and AST in pregnant women were significantly higher than that in the control group,the difference was significant (P <0.05);Gestational age and body weight in the observation group was significantly lower than that in the control group,which showed statistically significant (P <0.05);Meconium stained amniotic fluid rate,the rate of neonatal asphyxia,fetal distress in the observation group was significantly higher than that in control group ,so the difference was statistically significant (P <0.05).Conclusion The increased bile acid and liver enzymes in ICP pregnancy women may be the main cause of fetal hypoxia and bad prognosis of neonates,so it should be actively controlled.