CAJ | 학술논문

目的：探讨血清胱抑素 C（Cys C）联合尿微量白蛋白（mALB）对妊娠期高血压疾病（HDCP）早期肾损害的诊断价值。方法选取本院产科收治的 HDCP 孕妇150例（患者组）及正常妊娠孕妇147例（对照组），患者组孕妇按照病情严重程度进一步分为妊娠期高血压组60例，轻度子痫前期组51例，重度子痫前期组39例，检测患者组及对照组血清 Cys C、BUN、肌酐（SCr）及尿 mALB。结果患者组各指标水平明显高于对照组（P ＜0．05）；妊娠期高血压组与轻度子痫前期组各检测指标比较，BUN 与 SCr 指标无显著差异（P ＞0．05），CysC 与尿 mALB 差异有统计学意义（P ＜0．05）；轻度子痫前期组与重度子痫前期组各检测指标比较，差异均有统计学意义（P ＜0．05）。相关分析发现，患者组血清CysC与尿mALB水平呈正相关（r ＝0．671，P ＜0．05）。结论 HDCP 孕妇早期即存在血清 Cys C 及尿 mALB 水平增高，且随病情加重呈上升趋势，两者联合检测有利于尽早发现 HDCP 孕妇早期的肾损害。
목적：탐토혈청광억소 C（Cys C）연합뇨미량백단백（mALB）대임신기고혈압질병（HDCP）조기신손해적진단개치。방법선취본원산과수치적 HDCP 잉부150례（환자조）급정상임신잉부147례（대조조），환자조잉부안조병정엄중정도진일보분위임신기고혈압조60례，경도자간전기조51례，중도자간전기조39례，검측환자조급대조조혈청 Cys C、BUN、기항（SCr）급뇨 mALB。결과환자조각지표수평명현고우대조조（P ＜0．05）；임신기고혈압조여경도자간전기조각검측지표비교，BUN 여 SCr 지표무현저차이（P ＞0．05），CysC 여뇨 mALB 차이유통계학의의（P ＜0．05）；경도자간전기조여중도자간전기조각검측지표비교，차이균유통계학의의（P ＜0．05）。상관분석발현，환자조혈청CysC여뇨mALB수평정정상관（r ＝0．671，P ＜0．05）。결론 HDCP 잉부조기즉존재혈청 Cys C 급뇨 mALB 수평증고，차수병정가중정상승추세，량자연합검측유리우진조발현 HDCP 잉부조기적신손해。
Objective To explore early diagnosis of early renal injury in pregnancy patients with hypertensive disorder complicating pregnancy(HDCP)by detection of serum cystain C(Cys C)and urine microalbumin(mALB).Methods A total of 150 pregnant women with HDCP were in the study group and 147 normal pregnant women were in control group.The pregnant women in study group were further divided into gestational hypertension group (60 pregnant women),mild preeclampsia group(51 pregnant women)and severe preeclampsia group (39 pregnant women )ac-cording to severity of the disease;The levels of Cys C,BUN,Scr and microalbumin(mALB)were detected.Results The levels of Cys C,BUN,Scr and mALB in study group were significantly higher than those in control group(P <0.05).The difference in levels of BUN and Scr was not statistically significant (P >0.05).The levels of CysC and mALB were statistically significant be-tween the gestational hypertension group and the mild preeclampsia group.The difference in levels of BUN,Scr,Cys C and mALB was statistically significant between the mild preeclampsia group and the severe preeclampsia group (P <0.05).The difference was significant in close positive cor-rection between the level of Cys C and mALB (r =0.671,P <0.05).Conclusion The increas-ing levels of CysC and mALB cause the worsening of the diseases.It is helpful to diagnose early re-nal injury of HDCP by combinative detection of serum Cys C and urine mALB.