CAJ | 학술논문

目的：探讨血清中胰岛素生长因子-1（IGF-1）和胰岛素结合蛋白-3（IGFBP-3）在特发性身体矮小（ISS）诊断中的价值。方法36例 ISS 儿童及50例正常对照儿童，分为青春前期组及青春期组，用化学发光法测定血清 IGF-1和 IGFBP-3水平。结果 ISS 组与对照组 IGF-1和 IGFBP-3水平与年龄均存在显著正相关（r ＝0．435、r ＝0．718、P ＜0．01），青春期组血清IGF-1和 IGFBP-3水平均高于相应的青春前期组。ISS 儿童血清 IGF-1水平、IGFBP-3水平均显著低于对照组（P ＜0．01）。结论血清 IGF-1及 IGFBP-3水平检测对 ISS 儿童临床诊断、生长监测及 GH 治疗随诊有着重要的临床价值。
목적：탐토혈청중이도소생장인자-1（IGF-1）화이도소결합단백-3（IGFBP-3）재특발성신체왜소（ISS）진단중적개치。방법36례 ISS 인동급50례정상대조인동，분위청춘전기조급청춘기조，용화학발광법측정혈청 IGF-1화 IGFBP-3수평。결과 ISS 조여대조조 IGF-1화 IGFBP-3수평여년령균존재현저정상관（r ＝0．435、r ＝0．718、P ＜0．01），청춘기조혈청IGF-1화 IGFBP-3수평균고우상응적청춘전기조。ISS 인동혈청 IGF-1수평、IGFBP-3수평균현저저우대조조（P ＜0．01）。결론혈청 IGF-1급 IGFBP-3수평검측대 ISS 인동림상진단、생장감측급 GH 치료수진유착중요적림상개치。
Objective To explore the value of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3)in diagnosis of children with idiopathic short stature (ISS).Methods 36 ISS and 50 normal children were collected and divided into preadolescent group and adolescent group respectively.Serum IGF-1 and IGFBP-3 were detected by chemiluminescence analysis.Results There were significant positive correlations between age and the serum levels of IGF-1 and IGFBP-3(r =0.435,r =0.718,P <0.01)in both groups.The concentrations of IGF-1 and IGFBP-3 in adolescent group were significantly higher than those in preadolescent group,and the concentrations of IGF-1 and IGFBP-3 in ISS group were significantly lower than those in the control group (P <0.01).Conclusion The detections of IGF-I and IGFBP-3 have a great value in the diagnose,growth monitoring and the treatment with GH for children with ISS.