CAJ | 학술논문

目的：探讨肾康注射液对糖尿病肾病（DN）患者疗效及其对血清 C 反应蛋白（CRP）、白介素-6（IL-6）的影响。方法选取2012年1月-2014年1月2型糖尿病合并 DN 的患者120例，随机分为观察组和对照组，每组60例。对照组给予优质低蛋白饮食，以胰岛素控制血糖，控制血压，观察组在此基础上加用肾康注射液静脉滴注。观察2组患者的临床疗效、治疗前后空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、血肌酐（SCr）、24 h 尿蛋白定量（24 hUpro）、CRP、IL-6等指标的变化。结果观察组总有效率90．00％，显著高于对照组的75．00％（P ＜0．05）；治疗后上述各指标均较治疗前有显著改善（P ＜0．05或P ＜0．01）；组间比较，观察组各指标显著低于对照组（P ＜0．01）。结论肾康注射液可有效降低 DN 患者体内的 IL-6、CRP 表达水平，降低血脂、血糖，延缓 DN 患者的病情发展，改善预后。
목적：탐토신강주사액대당뇨병신병（DN）환자료효급기대혈청 C 반응단백（CRP）、백개소-6（IL-6）적영향。방법선취2012년1월-2014년1월2형당뇨병합병 DN 적환자120례，수궤분위관찰조화대조조，매조60례。대조조급여우질저단백음식，이이도소공제혈당，공제혈압，관찰조재차기출상가용신강주사액정맥적주。관찰2조환자적림상료효、치료전후공복혈당（FBG）、감유삼지（TG）、총담고순（TC）、혈기항（SCr）、24 h 뇨단백정량（24 hUpro）、CRP、IL-6등지표적변화。결과관찰조총유효솔90．00％，현저고우대조조적75．00％（P ＜0．05）；치료후상술각지표균교치료전유현저개선（P ＜0．05혹P ＜0．01）；조간비교，관찰조각지표현저저우대조조（P ＜0．01）。결론신강주사액가유효강저 DN 환자체내적 IL-6、CRP 표체수평，강저혈지、혈당，연완 DN 환자적병정발전，개선예후。
Objective To explore the clinical efficacy of Shenkang Injection and its influence on C-reactive protein (CRP)and interleukin-6 (IL-6)levels in patients with diabetic nephropathy (DN).Methods A total of 120 patients with type 2 diabetes mellitus combined with DN admitted in our hospital from Jan.2012 to Jan.2014 were randomly divided into observation group and con-trol group,60 cases for each.Control group was treated with high-quality protein diets and insulin to control blood glucose and pressure,on which basis observation group was added with intravenous injection of Shenkang Injection.Clinical efficacy,fasting blood glucose (FBG),Triglyceride (TG), total cholesterol (TC),serum creatinine (SCr),24 h urinary protein (24 hUpro),CRP and IL-6 level changes before and after treatment in both groups were observed.Results Clinical efficacy was 90.00% in observation group,evidently higher than 75.00% in control group (P <0.05). Aboveindexeswere all improvedobviously after treatment than treatment before (P < 0 .0 5 ,P <0.01)and were markedly lower in observation group than in control group (P <0.01).Conclusion Shenkang Injection can effectively reduce IL-6 and CRP levels and decrease blood glucose and pressure,prolong disease progression and improve prognosis in DN patients.