实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
15期
14-16
,共3页
缬沙坦%氨氯地平%高血压%糖尿病%血尿酸%胰岛素敏感指数
纈沙坦%氨氯地平%高血壓%糖尿病%血尿痠%胰島素敏感指數
힐사탄%안록지평%고혈압%당뇨병%혈뇨산%이도소민감지수
valsartan%amlodipine%hypertension%diabetics%blood uric acid%insulin sensi-tivity index
目的：探讨缬沙坦联合氨氯地平治疗老年高血压合并糖尿病的临床疗效及其对血糖、血脂和血尿酸水平的影响。方法选取120例老年高血压合并2型糖尿病患者为研究对象，随机分为2组，每组60例，联合组给予缬沙坦联合氨氯地平口服，单用组氨氯地平口服。观察2组患者的临床疗效、治疗前后血脂、空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素敏感指数（ISI）及血尿酸（UA）等指标的变化。结果联合组总有效率93．33％，单用组总有效率80．00％，组间比较具有显著差异（P ＜0．05）；治疗前2组血脂、UA 水平、FBG、FINS 及 ISI 无显著差异（P ＞0．05），治疗后联合组上述指标较治疗前均有显著改善（P ＜0．01），单用组与治疗前无显著差异（P ＞0．05）。结论缬沙坦联合氨氯地平治疗老年高血压合并糖尿病的临床疗效优于单用氨氯地平，且可显著改善脂肪代谢及胰岛素敏感性。
目的：探討纈沙坦聯閤氨氯地平治療老年高血壓閤併糖尿病的臨床療效及其對血糖、血脂和血尿痠水平的影響。方法選取120例老年高血壓閤併2型糖尿病患者為研究對象，隨機分為2組，每組60例，聯閤組給予纈沙坦聯閤氨氯地平口服，單用組氨氯地平口服。觀察2組患者的臨床療效、治療前後血脂、空腹血糖（FBG）、空腹胰島素（FINS）、胰島素敏感指數（ISI）及血尿痠（UA）等指標的變化。結果聯閤組總有效率93．33％，單用組總有效率80．00％，組間比較具有顯著差異（P ＜0．05）；治療前2組血脂、UA 水平、FBG、FINS 及 ISI 無顯著差異（P ＞0．05），治療後聯閤組上述指標較治療前均有顯著改善（P ＜0．01），單用組與治療前無顯著差異（P ＞0．05）。結論纈沙坦聯閤氨氯地平治療老年高血壓閤併糖尿病的臨床療效優于單用氨氯地平，且可顯著改善脂肪代謝及胰島素敏感性。
목적：탐토힐사탄연합안록지평치료노년고혈압합병당뇨병적림상료효급기대혈당、혈지화혈뇨산수평적영향。방법선취120례노년고혈압합병2형당뇨병환자위연구대상，수궤분위2조，매조60례，연합조급여힐사탄연합안록지평구복，단용조안록지평구복。관찰2조환자적림상료효、치료전후혈지、공복혈당（FBG）、공복이도소（FINS）、이도소민감지수（ISI）급혈뇨산（UA）등지표적변화。결과연합조총유효솔93．33％，단용조총유효솔80．00％，조간비교구유현저차이（P ＜0．05）；치료전2조혈지、UA 수평、FBG、FINS 급 ISI 무현저차이（P ＞0．05），치료후연합조상술지표교치료전균유현저개선（P ＜0．01），단용조여치료전무현저차이（P ＞0．05）。결론힐사탄연합안록지평치료노년고혈압합병당뇨병적림상료효우우단용안록지평，차가현저개선지방대사급이도소민감성。
Objective To explore clinical efficacy of valsartan combined with amlodipine on the level of blood sugar,serum lipid and blood uric acid of elderly patients with hypertension compli-cated with diabetics.Methods A total of 120 cases with hypertension complicated with diabetics were selected and divided into 2 groups.Combined-used group was given oral valsartan combined with amlodipine and single-amlodipine group was given amlodipine.Clinical efficacy and indexes of serum lipid,fasting blood-glucose (FBG),fasting insulin (FINS),insulin sensitivity index (ISI) and blood uric acid (UA)were observed.Results Total effective rate of combined-used group was 93.33% and single-amlodipine group was 80.00%,there was significant difference between 2 groups (P >0.05).there were no differences in the levels of serum lipid,FBG,FINS and ISI be-fore treatment (P >0.05).And the above mentioned indexes were significantly changed after treatment (P < 0 .0 1 ).there were no differences in single-amlodipine group before treatment (P >0.05).Conclusion The clinical effect of valsartan combined with amlodipine for treating el-derly patients with hypertension complicated with diabetics be superior to single-amlodipine group and can obviously improve fat metabolism and insulin sensitivity.
