CAJ | 학술논문

目的：观察甘精胰岛素联合二甲双胍治疗老年2型糖尿病（T2DM）的临床疗效，探讨其对血糖、高敏 C 反应蛋白（hs-CRP）及丙二醛（MDA）水平的影响。方法将72例老年 T2DM 患者随机分为治疗组和对照组，每组36例，对照组皮下注射甘精胰岛素，治疗组在此基础上给予二甲双胍，疗程均为6周。比较2组治疗后的临床疗效，治疗前后血糖指标、hs-CRP 及MDA 水平的变化，并观察不良反应发生情况。结果治疗组总有效率显著高于对照组（P ＜0．05）。治疗后，2组空腹血糖（FBG）、餐后2 h 血糖（2 hPG）及糖化血红蛋白（HbA1c）水平均较治疗前显著下降（P ＜0．01），其中治疗组降低幅度更为显著（P＜0．05或 P ＜0．01）。治疗后，2组 hs-CRP 及 MDA 水平均较治疗前显著降低（P ＜0．05或 P ＜0．01），且治疗组治疗后 hs-CRP 水平显著低于对照组（P ＜0．05）。结论甘精胰岛素联合二甲双胍能有效降低老年 T2DM 患者的血糖水平，缓解氧化应激程度，疗效显著。
목적：관찰감정이도소연합이갑쌍고치료노년2형당뇨병（T2DM）적림상료효，탐토기대혈당、고민 C 반응단백（hs-CRP）급병이철（MDA）수평적영향。방법장72례노년 T2DM 환자수궤분위치료조화대조조，매조36례，대조조피하주사감정이도소，치료조재차기출상급여이갑쌍고，료정균위6주。비교2조치료후적림상료효，치료전후혈당지표、hs-CRP 급MDA 수평적변화，병관찰불량반응발생정황。결과치료조총유효솔현저고우대조조（P ＜0．05）。치료후，2조공복혈당（FBG）、찬후2 h 혈당（2 hPG）급당화혈홍단백（HbA1c）수평균교치료전현저하강（P ＜0．01），기중치료조강저폭도경위현저（P＜0．05혹 P ＜0．01）。치료후，2조 hs-CRP 급 MDA 수평균교치료전현저강저（P ＜0．05혹 P ＜0．01），차치료조치료후 hs-CRP 수평현저저우대조조（P ＜0．05）。결론감정이도소연합이갑쌍고능유효강저노년 T2DM 환자적혈당수평，완해양화응격정도，료효현저。
Objective To explore the clinical efficacy of glargine combined with metformin for old patients with type 2 diabetes mellitus (T2DM)and its effect on the glucose,high-sensitivity C-reactive protein (hs-CRP)and malondialdehyde (MDA)levels.Methods Seventy-two old pa-tients with T2DM were randomly divided into treatment group and control group,36 cases in each group.The control group was subcutaneously injected glargine,while the treatment group was added metformin based on this.Both courses of treatment were 6 weeks.The clinical efficacy after treatment,changes of glucose-related indexes,hs-CRP and MDA levels before and after treatment were compared,and the incidence of adverse reactions was observed.Results The overall response rate of treatment group was obviously higher than in control group,with statistical significance(P <0.05).After treatment,the levels of fasting blood glucose (FBG),2 h postprandial glucose (2hPG)and glycosylated hemoglobin (HbA1c)in both groups went down significantly by compari-son to treatment before(P <0.01),in which the decreased range in treatment group was more sig-nificant(P <0.05 or P <0.01).Besides,hs-CRP and MDA levels in two groups after treatment were notably decreased(P <0.05 or P <0.01),and hs-CRP level in treatment group was markedly lower than in control group(P <0.05).Conclusion Glargine combined with metformin can effec-tively decrease the glucose level in old patients with T2DM,and alleviate the degree of oxidative stress,with significant efficacy.