CAJ | 학술논문

目的：探讨干扰素联合 TP 方案术前新辅助化疗方案在卵巢上皮性癌合并腹水患者治疗中的疗效。方法选取2010年1月-2012年12月本院卵巢上皮性癌合并腹水患者50例，患者均知情同意，行术前新辅助化疗，随机分为2组，其中25例（TPI 组）采取多西他赛＋卡铂＋干扰素方案，25例（TP 组）采取多西他赛＋卡铂方案，2周期化疗后均行卵巢癌减灭术，比较2组患者临床症状缓解、不良反应、减灭术满意率及术中情况。结果 TPI 组新辅助化疗近期有效率为64％，TP 组为52％，2组比较差异无统计学意义（P ＞0．05）。TPI 组腹水消退明显优于 TP 组（P ＜0．05）；卵巢癌减灭术满意率92％高于 TP 组80％，但差异无统计学意义（P ＞0．05）；手术情况 TPI 组好于 TP 组，差异有统计学意义（P ＜0．05）；TPI 组患者骨髓抑制及发热不良反应发生率较 TP 组明显增加，差异有统计学意义（P ＜0．05），消化道不良反应发生率2组无显著差异（P ＞0．05）。结论干扰素联合 TP 方案治疗卵巢上皮性癌合并腹水患者，能更好地缓解临床症状、缩短手术时间并减少术中出血量，但骨髓抑制等不良反应加重。
목적：탐토간우소연합 TP 방안술전신보조화료방안재란소상피성암합병복수환자치료중적료효。방법선취2010년1월-2012년12월본원란소상피성암합병복수환자50례，환자균지정동의，행술전신보조화료，수궤분위2조，기중25례（TPI 조）채취다서타새＋잡박＋간우소방안，25례（TP 조）채취다서타새＋잡박방안，2주기화료후균행란소암감멸술，비교2조환자림상증상완해、불량반응、감멸술만의솔급술중정황。결과 TPI 조신보조화료근기유효솔위64％，TP 조위52％，2조비교차이무통계학의의（P ＞0．05）。TPI 조복수소퇴명현우우 TP 조（P ＜0．05）；란소암감멸술만의솔92％고우 TP 조80％，단차이무통계학의의（P ＞0．05）；수술정황 TPI 조호우 TP 조，차이유통계학의의（P ＜0．05）；TPI 조환자골수억제급발열불량반응발생솔교 TP 조명현증가，차이유통계학의의（P ＜0．05），소화도불량반응발생솔2조무현저차이（P ＞0．05）。결론간우소연합 TP 방안치료란소상피성암합병복수환자，능경호지완해림상증상、축단수술시간병감소술중출혈량，단골수억제등불량반응가중。
Objective To investigate clinical effects of interferon combined with neoadju-vant chemotherapy on ovarian cancer complicated with ascites.Methods A total of 50 patients with ovarian cancer complicated with ascites admitted in the first hospital of the China Medical U-niversity during 2010 to 2012 were analyzed retrospectively.Totally 25 patients were treated by preoperative neoadjuvant chemotherapy with TPI(docetaxel,carboplatin and interferon)regimen, and others received TP(docetaxel and carboplatin)regimen.The resections were taken after 2 cy-cles of treatment.The remission of the clinical symptoms,side effects of chemotherapy,resection rate of satisfaction and resection situations was analyzed.Results The efficacy rates of TPI and TP regimen were 64% and 52% respectively.There was no significant difference between the two groups(P <0.05).But the reduction of ascites of TPI regimen was faster.The resection rate of satisfaction was no significant difference between the two groups,while the resection situations of TPI regimen were better.Some of side effects in TP regimen,such as bone marrow suppression, were slighter than TPI regimen.Conclusion Patients with ovarian cancer complicated with as-cites could relieve symptoms and resection situations from interferon combined with neoadjuvant chemotherapy,shorten operative time and bleeding,but increase the adverse effects.