CAJ | 학술논문

目的：观察奥美沙坦及奥美沙坦联合前列地尔对糖尿病伴微量蛋白尿的干预。方法选择2012年11月-2013年11月本科室确诊为2型糖尿病40例患者，分为单用奥美沙坦组（A 组）、奥美沙坦联合前列地尔组（B 组），治疗2周。观察治疗前后2组尿微量白蛋白、肾小球率过滤、血压、高敏 C 反应蛋白及血凝的变化。结果疗程内，B 组较 A 组对糖尿病伴微量蛋白尿的影响差异有统计学意义；2组对肾小球率过滤、血压、高敏 C 反应蛋白影响差异也有统计学意义；2组对血凝改变差异无统计学意义。结论奥美沙坦联合前列地尔短期内降低尿微量白蛋白、肾小球率过滤、血压、高敏 C 反应蛋白，与其抑制肾素-血管紧张素系统、抗肾脏局部高凝及抑制微炎症状态相关。
목적：관찰오미사탄급오미사탄연합전렬지이대당뇨병반미량단백뇨적간예。방법선택2012년11월-2013년11월본과실학진위2형당뇨병40례환자，분위단용오미사탄조（A 조）、오미사탄연합전렬지이조（B 조），치료2주。관찰치료전후2조뇨미량백단백、신소구솔과려、혈압、고민 C 반응단백급혈응적변화。결과료정내，B 조교 A 조대당뇨병반미량단백뇨적영향차이유통계학의의；2조대신소구솔과려、혈압、고민 C 반응단백영향차이야유통계학의의；2조대혈응개변차이무통계학의의。결론오미사탄연합전렬지이단기내강저뇨미량백단백、신소구솔과려、혈압、고민 C 반응단백，여기억제신소-혈관긴장소계통、항신장국부고응급억제미염증상태상관。
Objective To observe the impact of olmesartan and alprostadi on diabetic pa-tients with microalbuminuria.Methods 40 patients were divided into group A given olmesartan and B group given olmesartan and alprostadil.The two groups were treated for 2 weeks.The changes of microalbuminuria 、glomerular filtration rate,blood pressure,high-sensitivity C-reactive protein and blood clotting were observed.Results During the treament,there was statistically significant in the effect of microalbuminuria in group B than that in group A;There were signifi-cant difference in two groups of glomerular filtration rate,blood pressure,high-sensitivity C-reac-tive protein,and there was no significant difference in two groups of clotting change.Conclusion In group B,reduced microalbuminuria,glomerular filtration rate,blood pressure,high-sensitivity C-reactive protein was related with inhibition of the renin-angiotensin,and related to anti-kidney local hypercoagulable and micro-inflammatory state.